Abstract：
Nanoformulations in vaccinology provide antigen stability and enhanced immunogenicity, in addition to providing targeted delivery and controlled release. In the last years, much research has been focused on vaccine development using virus-like particles, liposomes, emulsions, polymeric, lipid, and inorganic nanoparticles. Importantly, nanoparticle interactions with innate and adaptive immune systems must be clearly understood to guide the rational development of nanovaccines. This review provides a recap and updates on different aspects advocating nanoparticles as promising antigen carriers and immune cell activators for vaccination. Moreover, it offers a discussion of how the physicochemical properties of nanoparticles are modified to target specific cells and improve vaccine efficacy.
摘要：
疫苗学中的纳米制剂提供抗原稳定性和增强的免疫原性，除了提供靶向递送和控制释放。在过去的几年里，许多研究都集中在使用病毒样颗粒的疫苗开发上，脂质体，乳液，聚合物,脂质，和无机纳米粒子。重要的是,必须清楚地了解纳米粒子与先天和适应性免疫系统的相互作用，以指导纳米疫苗的合理发展。这篇综述提供了关于倡导纳米粒子作为有前途的抗原载体和免疫细胞激活剂用于疫苗接种的不同方面的回顾和更新。此外，它讨论了如何修饰纳米粒子的物理化学性质以靶向特定细胞并提高疫苗效力。
