{Reference Type}: Journal Article
{Title}: Nanocarriers of antigen proteins for vaccine delivery.
{Author}: Lopes Chaves L;Dourado D;Prunache IB;Manuelle Marques da Silva P;Tacyana Dos Santos Lucena G;Cardoso de Souza Z;Muniz Mendes Freire de Moura P;Nunes Bordallo H;Rocha Formiga F;de Souza Rebouças J;
{Journal}: Int J Pharm
{Volume}: 659
{Issue}: 0
{Year}: 2024 Jun 25
{Factor}: 6.51
{DOI}: 10.1016/j.ijpharm.2024.124162
{Abstract}: Nanoformulations in vaccinology provide antigen stability and enhanced immunogenicity, in addition to providing targeted delivery and controlled release. In the last years, much research has been focused on vaccine development using virus-like particles, liposomes, emulsions, polymeric, lipid, and inorganic nanoparticles. Importantly, nanoparticle interactions with innate and adaptive immune systems must be clearly understood to guide the rational development of nanovaccines. This review provides a recap and updates on different aspects advocating nanoparticles as promising antigen carriers and immune cell activators for vaccination. Moreover, it offers a discussion of how the physicochemical properties of nanoparticles are modified to target specific cells and improve vaccine efficacy.