Abstract：
Since the effects of flaxseed supplementation on lipid profile and liver enzymes are still controversial, a meta-analysis of randomized controlled trials was conducted in the present study to assess the effect of flaxseed supplementation on lipid profile and liver enzymes. The study was designed, conducted, and reported according to the guidelines of the 2020 preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. A systematic and comprehensive search was performed in several databases from inception up to January 10, 2024. The meta-analysis on the impact of flaxseed supplementation on lipid profile and liver enzymes indicates that the overall effect of flaxseed supplementation on triglycerides, combining different doses, revealed a significant reduction with a WMD of - 230.72 (-53.95, - 27.49) and a P-value of 0.010. High-density lipoprotein (HDL) demonstrated a positive effect, with an overall WMD of 1.82 (0.27, 3.38) and a P-value of 0.021, indicating an increase in HDL levels. The liver enzymes AST and ALT displayed reductions in their levels, with overall WMDs of - 21.18 (-2.95, 0.59) and - 24.83 (-8.74, - 20.91), respectively. Subgroup analysis based on dosage revealed more pronounced reductions in ALT levels for doses below 2000 mg/day. Findings from this study suggest that a flaxseed supplement might be beneficial to modulate the blood lipid profile and liver enzymes.
摘要：
由于亚麻籽补充剂对血脂和肝酶的影响仍然存在争议，本研究对随机对照试验进行了荟萃分析,以评估补充亚麻籽对血脂和肝酶的影响.这项研究是设计的，进行了,并根据2020年系统评价和荟萃分析（PRISMA）声明首选报告项目的指南进行报告。从开始到2024年1月10日，在多个数据库中进行了系统和全面的搜索。关于亚麻籽补充剂对血脂和肝酶的影响的荟萃分析表明，亚麻籽补充剂对甘油三酯的总体影响，结合不同的剂量，结果显示，WMD为-30.72（-53.95，-7.49），P值为0.010，显着降低。高密度脂蛋白（HDL）显示出积极的作用，总体WMD为1.82（0.27，3.38），P值为0.021，表明HDL水平升高。肝酶AST和ALT显示其水平降低，总体WMD为-1.18（-2.95，0.59）和-4.83（-8.74，-0.91），分别。基于剂量的亚组分析显示，剂量低于2000mg/天的ALT水平降低更明显。这项研究的结果表明，亚麻籽补充剂可能有利于调节血脂和肝酶。
