Abstract：
Novel strategies employing mechano-transducing materials eliciting biological outcomes have recently emerged for controlling cellular behaviour. Targeted cellular responses are achieved by manipulating physical, chemical, or biochemical modification of material properties. Advances in techniques such as nanopatterning, chemical modification, biochemical molecule embedding, force-tuneable materials, and artificial extracellular matrices are helping understand cellular mechanotransduction. Collectively, these strategies manipulate cellular sensing and regulate signalling cascades including focal adhesions, YAP-TAZ transcription factors, and multiple osteogenic pathways. In this minireview, we are providing a summary of the influence that these materials, particularly titanium-based orthopaedic materials, have on cells. We also highlight recent complementary methodological developments including, but not limited to, the use of metabolomics for identification of active biomolecules that drive cellular differentiation.
摘要：
最近出现了采用机械转导材料引起生物学结果的新策略，用于控制细胞行为。有针对性的细胞反应是通过操纵物理，化学,或生化改性材料的性质。纳米图案化等技术的进步，化学改性,生化分子嵌入，力可调材料，人工细胞外基质有助于理解细胞机械传导。总的来说，这些策略操纵细胞传感和调节信号级联，包括粘着斑，YAP-TAZ转录因子,和多种成骨途径。在这篇小型评论中，我们提供了这些材料的影响的摘要，特别是钛基矫形材料，在细胞上。我们还强调了最近的补充方法发展，包括，但不限于,使用代谢组学鉴定驱动细胞分化的活性生物分子。
