PDF(Pubmed)
Abstract：
Chronic fatigue syndrome (CFS) causes great harm to individuals and society. Elucidating the pathogenesis of CFS and developing safe and effective treatments are urgently needed. This paper reviews the functional changes in the hypothalamus-pituitary-adrenal (HPA) axis in patients with CFS and the associated neuroendocrine mechanisms. Despite some controversy, the current mainstream research evidence indicates that CFS patients have mild hypocortisolism, weakened daily variation in cortisol, a weakened response to the HPA axis, and an increase in negative feedback of the HPA axis. The relationship between dysfunction of the HPA axis and the typical symptoms of CFS are discussed, and the current treatment methods are reviewed.
摘要：
慢性疲劳综合征（CFS）对个人和社会造成了极大的危害。迫切需要阐明CFS的发病机制并开发安全有效的治疗方法。本文综述了CFS患者下丘脑-垂体-肾上腺（HPA）轴的功能变化及其相关的神经内分泌机制。尽管有一些争议,目前的主流研究证据表明，CFS患者有轻度皮质醇减少症，皮质醇的每日变化减弱，对HPA轴的反应减弱，以及HPA轴的负反馈增加。讨论了HPA轴功能障碍与CFS典型症状之间的关系，并对目前的治疗方法进行了综述。
