PDF(Pubmed)
Abstract：
Bone lesions in sarcoidosis are more common than previously known. A 59-year-old female with a history of sarcoidosis was referred due to suspected lung cancer. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) revealed numerous bone lesions in addition to abnormal uptake by pulmonary nodules and mediastinal lymph nodes, which mimicked metastatic advanced lung cancer. Biopsy of bone lesions detected epithelioid cell granuloma consistent with bone sarcoidosis. Moreover, prednisolone treatment was tried to exclude malignant disease. One month after prednisolone administration, bone lesions and other abnormal uptake disappeared on PET/CT. Bone sarcoidosis is often asymptomatic and is discovered incidentally as multiple lesions that may require differentiation from malignant disease. Biopsy of bone lesions and administration of corticosteroids may be useful for accurate diagnosis.
摘要：
结节病的骨病变比以前已知的更常见。一名有结节病病史的59岁女性因怀疑肺癌而转诊。18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）显示，除了肺结节和纵隔淋巴结的异常摄取外，还有许多骨病变。模仿转移性晚期肺癌。骨病变活检发现上皮样细胞肉芽肿与骨结节病一致。此外，泼尼松龙治疗试图排除恶性疾病。泼尼松龙给药后一个月，PET/CT显示骨病变和其他异常摄取消失。骨结节病通常无症状，偶然发现为多发性病变，可能需要与恶性疾病区分。骨病变的活检和皮质类固醇的给药可能有助于准确诊断。
