PDF(Pubmed)
Abstract：
This case report describes the application of ultrasound renal denervation (uRDN) using the Paradise System in a patient with heart failure with preserved ejection fraction. Initially, the cardiac sympathetic nerve activity of the patient exhibited a late heart/mediastinum (H/M) ratio of 2.00 and a washout rate of 66.0% by cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy. Subsequently, the patient underwent transfemoral uRDN targeting the left, right upper, and right lower renal arteries. At the 6 month follow-up, no significant change was observed in 123I-MIBG findings; however, the estimated stressed blood volume (eSBV) decreased from 1722 to 1029 mL/70 kg. At 18 months, 123I-MIBG findings improved, with the late H/M ratio reaching 2.76 and the washout rate decreasing to 43.1%. This case report highlights the potential of uRDN in reducing eSBV within 6 months and subsequently improving cardiac sympathetic nerve activity at the 18 month follow-up.
摘要：
此病例报告描述了使用Paradise系统在射血分数保留的心力衰竭患者中使用超声肾脏去神经（uRDN）的应用。最初，通过心脏碘-123间碘苄基胍(123I-MIBG)闪烁显像,患者的心脏交感神经活动显示晚期心脏/纵隔(H/M)比率为2.00,洗脱率为66.0%.随后，患者接受了以左侧为目标的经股动脉uRDN，右上,和右下肾动脉.在6个月的随访中，在123I-MIBG结果中没有观察到显著变化;然而,估计的应激血容量（eSBV）从1722降至1029mL/70kg。18个月时,123I-MIBG的发现有所改善，后期H/M比达到2.76，冲洗率降至43.1％。该病例报告强调了uRDN在6个月内降低eSBV并随后在18个月随访时改善心脏交感神经活性的潜力。
