{Reference Type}: Case Reports
{Title}: Cardiac sympathetic nerve activity trends after renal denervation in heart failure with preserved ejection fraction.
{Author}: Shiraki T;Mizuno H;Kishi T;Asakura M;Asanoi H;Yasumura Y;Sakata Y;
{Journal}: ESC Heart Fail
{Volume}: 11
{Issue}: 4
{Year}: 2024 Aug 24
{Factor}: 3.612
{DOI}: 10.1002/ehf2.14770
{Abstract}: This case report describes the application of ultrasound renal denervation (uRDN) using the Paradise System in a patient with heart failure with preserved ejection fraction. Initially, the cardiac sympathetic nerve activity of the patient exhibited a late heart/mediastinum (H/M) ratio of 2.00 and a washout rate of 66.0% by cardiac iodine-123 metaiodobenzylguanidine (123I-MIBG) scintigraphy. Subsequently, the patient underwent transfemoral uRDN targeting the left, right upper, and right lower renal arteries. At the 6 month follow-up, no significant change was observed in 123I-MIBG findings; however, the estimated stressed blood volume (eSBV) decreased from 1722 to 1029 mL/70 kg. At 18 months, 123I-MIBG findings improved, with the late H/M ratio reaching 2.76 and the washout rate decreasing to 43.1%. This case report highlights the potential of uRDN in reducing eSBV within 6 months and subsequently improving cardiac sympathetic nerve activity at the 18 month follow-up.