Abstract：
UNASSIGNED: Preventative strategies that minimize hemodialysis access complications remain limited.
UNASSIGNED: This study aimed to address this gap by developing a Caprine cannulation model to investigate the impact of repeated cannulations on vascular access patency rates.
UNASSIGNED: In this pilot study, a meta-analysis was conducted using experimental control data from four trials to explore the impact of Caprine breed (independent variable) on the dependent variables that affect hemodialysis cannulation, including AVF growth, AVF depth, and flow rate.
UNASSIGNED: Arteriovenous Fistulas (AVFs) were created using the carotid artery and jugular vein in the necks of seven goats from the French alpine, dwarf, and pygmy breeds. All seven AVFs exhibited vessel remodeling patterns similar to that observed in humans and remained patent, enabling hemodialysis access over the 6 month study.
UNASSIGNED: Over the course of 18 weeks, a total of 291 cannulations were completed using standard 15 g dialysis needles without complications demonstrating the feasibility of using the Caprine species as a cannulation model. The ease of access coupled with the animals\' cooperative behavior further contributes to the suitability of the Caprine species for hemodialysis investigations. Notably, no infections or clinically significant incidents were observed throughout the study.
UNASSIGNED: The stability of AVF patency and flow underscores the viability and potential of the Caprine species animal model as a valuable research platform for exploring interventions aimed at improving vascular access survival in hemodialysis patients.
UNASSIGNED: This study aimed to address this gap by developing a Caprine cannulation model to investigate the impact of repeated cannulations on vascular access patency rates.
UNASSIGNED: In this pilot study, a meta-analysis was conducted using experimental control data from four trials to explore the impact of Caprine breed (independent variable) on the dependent variables that affect hemodialysis cannulation, including AVF growth, AVF depth, and flow rate.
UNASSIGNED: Arteriovenous Fistulas (AVFs) were created using the carotid artery and jugular vein in the necks of seven goats from the French alpine, dwarf, and pygmy breeds. All seven AVFs exhibited vessel remodeling patterns similar to that observed in humans and remained patent, enabling hemodialysis access over the 6 month study.
UNASSIGNED: Over the course of 18 weeks, a total of 291 cannulations were completed using standard 15 g dialysis needles without complications demonstrating the feasibility of using the Caprine species as a cannulation model. The ease of access coupled with the animals\' cooperative behavior further contributes to the suitability of the Caprine species for hemodialysis investigations. Notably, no infections or clinically significant incidents were observed throughout the study.
UNASSIGNED: The stability of AVF patency and flow underscores the viability and potential of the Caprine species animal model as a valuable research platform for exploring interventions aimed at improving vascular access survival in hemodialysis patients.
摘要：
■减少血液透析并发症的预防策略仍然有限。
■本研究旨在通过开发Caprine插管模型来研究重复插管对血管通路通畅率的影响来解决这一差距。
■在这项试点研究中，使用来自四项试验的实验对照数据进行荟萃分析，以探索Caprine品种（自变量）对影响血液透析插管的因变量的影响，包括AVF增长，AVF深度,和流量。
■使用来自法国高山的七只山羊的颈部的颈动脉和颈静脉创建动静脉瘘（AVF），侏儒,和侏儒品种。所有七个AVF都表现出与人类相似的血管重塑模式，并保持专利，在6个月的研究中实现血液透析。
■在18周的过程中，使用标准的15g透析针头共完成291个插管,没有出现并发症,这表明使用Caprine物种作为插管模型的可行性.易于进入，再加上动物的合作行为，进一步有助于山羊物种适合于血液透析研究。值得注意的是,在整个研究期间未观察到感染或有临床意义的事件.
■AVF通畅和血流的稳定性强调了Caprine物种动物模型作为探索旨在改善血液透析患者血管通路存活率的干预措施的有价值的研究平台的可行性和潜力。
■本研究旨在通过开发Caprine插管模型来研究重复插管对血管通路通畅率的影响来解决这一差距。
■在这项试点研究中，使用来自四项试验的实验对照数据进行荟萃分析，以探索Caprine品种（自变量）对影响血液透析插管的因变量的影响，包括AVF增长，AVF深度,和流量。
■使用来自法国高山的七只山羊的颈部的颈动脉和颈静脉创建动静脉瘘（AVF），侏儒,和侏儒品种。所有七个AVF都表现出与人类相似的血管重塑模式，并保持专利，在6个月的研究中实现血液透析。
■在18周的过程中，使用标准的15g透析针头共完成291个插管,没有出现并发症,这表明使用Caprine物种作为插管模型的可行性.易于进入，再加上动物的合作行为，进一步有助于山羊物种适合于血液透析研究。值得注意的是,在整个研究期间未观察到感染或有临床意义的事件.
■AVF通畅和血流的稳定性强调了Caprine物种动物模型作为探索旨在改善血液透析患者血管通路存活率的干预措施的有价值的研究平台的可行性和潜力。
