PDF(Pubmed)
Abstract：
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However, there are limited drugs targeting the treatment of DN. Owing to this, it is highly crucial to investigate the pathogenesis and potential therapeutic targets of DN. The process of ferroptosis is a type of regulated cell death (RCD) involving the presence of iron, distinct from autophagy, apoptosis, and pyroptosis. A primary mechanism of ferroptosis is associated with iron metabolism, lipid metabolism, and the accumulation of ROS. Recently, many studies testified to the significance of ferroptosis in kidney tissue under diabetic conditions and explored the drugs targeting ferroptosis in DN therapy. Our review summarized the most current studies between ferroptosis and DN, along with investigating the significant processes of ferroptosis in different kidney cells, providing a novel target treatment option for DN.
摘要：
糖尿病肾病(DN)是糖尿病的严重并发症,对公众造成实质性威胁，受到全球关注。然而,目前靶向治疗DN的药物有限。正因为如此,探讨DN的发病机制和潜在的治疗靶点至关重要。铁死亡的过程是一种涉及铁的存在的调节性细胞死亡（RCD），不同于自噬，凋亡，和焦亡。铁死亡的主要机制与铁代谢有关，脂质代谢，以及ROS的积累。最近,许多研究证明了糖尿病条件下肾脏组织铁凋亡的意义，并探索了针对铁凋亡的药物在DN治疗中的作用。我们的综述总结了铁中毒和DN之间的最新研究，随着研究不同肾细胞中铁死亡的重要过程，为DN提供了一种新的靶向治疗选择。
