Abstract：
Objective: The purpose of this study was to evaluate the association between the single nucleotide polymorphisms (SNPs) (EGR3 rs1996147; EGR4 rs3813226, rs6747506; ERBB3 rs2292238; and ERBB4 rs707284, rs7560730) and the risk of schizophrenia (SZ) in a Chinese population. Materials and Methods: We conducted a case-control study, including 248 patients with SZ and 236 healthy controls matched for age and sex. The Mass-array platform was used to detect all the genotypes of the SNPs. Results: The results revealed that the EGR3 rs1996147 AA genotype was associated with borderline decreased SZ risk (AA vs. GG: adjusted OR = 0.43, 95% CI: 0.18-1.02, p = 0.06). However, no significant correlation was found between the other SNPs and overall SZ risk. Subgroup analysis also failed to show any significant association between all SNPs and the risk of SZ. Conclusion: In summary, this study revealed that the EGR3 rs1996147 AA genotype was associated with a borderline risk for SZ.
摘要：
目的：本研究的目的是评估单核苷酸多态性（SNP）（EGR3rs1996147；EGR4rs3813226，rs6747506；ERBB3rs2292238；和ERBB4rs707284，rs7560730）与中国人群精神分裂症（SZ）风险之间的关系。材料和方法：我们进行了病例对照研究，包括248例SZ患者和236例年龄和性别相匹配的健康对照。Mass-array平台用于检测SNP的所有基因型。结果：结果显示，EGR3rs1996147AA基因型与SZ风险降低相关（AA与GG：调整后的OR=0.43，95%CI：0.18-1.02，p=0.06）。然而,其他SNPs与整体SZ风险之间未发现显著相关性.亚组分析也未能显示所有SNP与SZ风险之间的任何显著关联。结论：总之，这项研究表明，EGR3rs1996147AA基因型与SZ的临界风险相关。
