IIa 类 HDAC4 和 HDAC7 协同调节 Th17 细胞分化中的基因转录。
关键词: HDAC4 and HDAC7 Th17 cell differentiation drug discovery gene transcription
Mesh : Animals Th17 Cells / cytology metabolism immunology Histone Deacetylases / metabolism genetics Cell Differentiation Mice Colitis / genetics metabolism immunology Transcription, Genetic Transcription Factors / metabolism genetics Nuclear Receptor Co-Repressor 2 / metabolism genetics Interleukin-17 / metabolism Gene Expression Regulation Mice, Inbred C57BL Humans Repressor Proteins / metabolism genetics Interleukin-2 / metabolism Nuclear Receptor Co-Repressor 1
来 源:
DOI:10.1073/pnas.2312111121
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