PDF(Pubmed)
Abstract：
This study evaluated if vasoactive intestinal polypeptide (VIP) influences growth performance, nutrient digestibility, nitrogen balance, and digestive enzyme activity. Sixteen wether lambs (69.6 ± 1.9 kg) were housed in individual pens, adapted to a corn grain-based diet, and randomly assigned to 2 treatment groups. Lambs were injected intraperitoneally every other day for 28 d with saline (0.9% NaCl) containing no VIP (n = 8; control) or containing VIP (n = 8; 1.3 nmol/kg body weight [BW]). All lambs were transferred to individual metabolic crates for the final 7 d of the experiment to measure nitrogen balance and nutrient digestibility. At the end of the treatment period, lambs were slaughtered, and pancreatic tissue, small intestinal tissue, and rumen fluid were collected for protein, digestive enzymes, ruminal pH, and volatile fatty acid (VFA) analyses. Lambs treated with VIP had greater final BW, average daily gain, and gain:feed (P = 0.01, 0.05, 0.03, respectively). No differences between treatment groups were observed (P ≥ 0.25) for nutrient intake, digestibility, nitrogen retention, ruminal pH, and VFA concentrations. Moreover, VIP treatment did not influence (P ≥ 0.19) plasma glucose, urea N, and insulin concentrations. Treatment with VIP increased (P = 0.03) relative cecum weight (g/kg BW) and decreased (P = 0.05) relative brain weight. Pancreatic and intestinal digestive enzyme activities, except for duodenal maltase (P = 0.02), were not influenced (P ≥ 0.09) by VIP treatment. These data suggest that the administration of VIP may have potential to improve average daily gain and gain:feed in lambs fed grain-based diets.
This research explored the influence of vasoactive intestinal polypeptide (VIP), an anti-inflammatory mediator, in lambs fed a high-concentrate finishing diet on growth performance, nutrient digestibility, nitrogen balance, and digestive enzyme activity. Wether lambs were fed a whole corn grain-based diet containing no added forage and randomly assigned to either the VIP or control group. Lambs received intraperitoneal saline injections with or without VIP every second day over a 28-d treatment period. Average daily gain and gain:feed ratio was positively influenced by VIP. However, treatment did not affect dry matter intake, nitrogen balance, nutrient digestibility, and digestive enzyme activity. These data indicate exogenous VIP treatment may influence growth in lambs fed a high-concentrate diet.
This research explored the influence of vasoactive intestinal polypeptide (VIP), an anti-inflammatory mediator, in lambs fed a high-concentrate finishing diet on growth performance, nutrient digestibility, nitrogen balance, and digestive enzyme activity. Wether lambs were fed a whole corn grain-based diet containing no added forage and randomly assigned to either the VIP or control group. Lambs received intraperitoneal saline injections with or without VIP every second day over a 28-d treatment period. Average daily gain and gain:feed ratio was positively influenced by VIP. However, treatment did not affect dry matter intake, nitrogen balance, nutrient digestibility, and digestive enzyme activity. These data indicate exogenous VIP treatment may influence growth in lambs fed a high-concentrate diet.
摘要：
这项研究评估了血管活性肠多肽（VIP）是否会影响生长性能，营养素消化率，氮平衡，和消化酶活性。将16只羔羊（69.6±1.9千克）饲养在单个围栏中，适应以玉米粒为基础的饮食，并随机分配到2个治疗组。每隔一天，用不含VIP（n=8；对照）或含VIP（n=8；1.3nmol/kgBW）的盐水（0.9％NaCl）腹膜内注射羔羊28天。在实验的最后七天,将所有羔羊转移到单独的代谢板条箱中,以测量氮平衡和养分消化率。在治疗期结束时，羔羊被宰杀,和胰腺组织，小肠组织,并收集瘤胃液中的蛋白质，消化酶，瘤胃pH,和挥发性脂肪酸(VFA)分析。用VIP处理的羔羊最终体重更大，平均每日收益，和增益：饲料（分别为P=0.01，0.05，0.03）。治疗组之间的营养摄入量没有差异（P≥0.25），消化率，氮保留,瘤胃pH,和VFA浓度。此外，VIP治疗不影响（P≥0.19）血浆葡萄糖，尿素N,和胰岛素浓度。用VIP治疗增加(P=0.03)相对盲肠重量(g/kg体重)和减少(P=0.05)相对脑重量。胰腺和肠道消化酶活性，除十二指肠麦芽糖外（P=0.02），不受VIP治疗的影响(P≥0.09)。这些数据表明，VIP的施用可能具有改善平均日增重和增重的潜力：饲喂谷物饮食的羔羊。
