通过构建片段策略发现新型 FGFR4 抑制剂。
关键词: FGFR4 fragment hit identification kinase inhibitor small molecule
Mesh : Receptor, Fibroblast Growth Factor, Type 4 / antagonists & inhibitors metabolism Humans Structure-Activity Relationship Drug Discovery Molecular Structure Dose-Response Relationship, Drug Protein Kinase Inhibitors / pharmacology chemistry chemical synthesis Antineoplastic Agents / pharmacology chemistry chemical synthesis Cell Proliferation / drug effects Drug Screening Assays, Antitumor Carcinoma, Hepatocellular / drug therapy pathology metabolism
来 源:
DOI:10.1080/14756366.2024.2343350
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