PDF(Pubmed)
Abstract：
Introduction Dengue is a tropical viral disease caused by dengue virus with varied severity ranging from dengue fever to dengue shock syndrome. In dengue infection, there is thrombocytopenia with platelet activation. According to various proposed theories, activation of platelets during thrombocytopenia leads to changes in platelet parameters like mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), and platelet index (PI). So, this study was conducted to correlate platelet parameters with the severity of thrombocytopenia in children with dengue fever at a tertiary care hospital. Methods An observational cross-sectional study was conducted on 72 children below 18 years admitted with dengue infection at a tertiary care hospital. All 72 patients were divided into three groups depending on platelet count. Group I included individuals with a platelet count less than 50000/mm3, while group II comprised patients with platelet counts ranging between 50001/mm3 and 100000/mm3, and group III encompassed individuals with platelet counts exceeding 100001/mm3. Platelet parameters like MPV, PDW, PCT, and PI were analyzed on day one and day three of admission. These parameters on day one and day three were correlated with the severity of thrombocytopenia in all three groups. Results PCT values on day one and day three were statistically significant (p<0.05) in all three groups with p-value <0.001 with profound positive correlation, which means PCT value decreases with increasing severity of thrombocytopenia. PI in group I was statistically significant on day one (p=0.009) but not on day three (p=0.063). PI in group II was statistically significant (p<0.05) on day three (p=0.002), while in group III, PI was significant statistically on day one (p<0.001). MPV in group I, on day one (p=0.006) and in group II, on day three (p= 0.049) were statistically significant (p<0.05). PDW was statistically significant only on day one (p=0.031) in group I, while was not significant in groups II and III. Conclusion MPV, PDW, and PCT increase with a decrease in platelet count, whereas there is an increase in PI. These platelet indices could be used to predict the severity of thrombocytopenia and severity of the dengue fever. Along with MPV and PDW, PCT could be used to assess the severity of the disease progression.
摘要：
引言登革热是由登革热病毒引起的热带病毒性疾病,具有从登革热到登革热休克综合征的不同严重程度。在登革热感染中，血小板减少伴血小板活化。根据各种提出的理论，血小板减少症期间血小板的活化导致血小板参数的变化，如平均血小板体积（MPV），血小板分布宽度（PDW），plateletcrit（PCT），和血小板指数(PI)。所以,本研究的目的是将三级医院登革热患儿的血小板参数与血小板减少的严重程度相关联.方法对某三级医院收治的72名18岁以下登革热感染儿童进行观察性横断面研究。根据血小板计数将所有72例患者分为三组。第I组包括血小板计数小于50000/mm3的个体,而第II组包括血小板计数在50001/mm3和100000/mm3之间的患者,第III组包括血小板计数超过100001/mm3的个体。血小板参数像MPV,PDW,PCT,和PI在入院的第一天和第三天进行分析。第一天和第三天的这些参数与所有三组中血小板减少症的严重程度相关。结果3组第1天和第3天的PCT值均具有统计学意义（p<0.05），p值<0.001，呈正相关。这意味着PCT值随着血小板减少严重程度的增加而降低。第I组的PI在第1天具有统计学意义（p=0.009），但在第3天没有统计学意义（p=0.063）。II组PI在第3天（p=0.002）有统计学意义（p<0.05），而在第三组中，第一天的PI具有统计学意义（p<0.001）。I组MPV,在第1天（p=0.006）和第II组中，在第3天（p=0.049）有统计学意义（p<0.05）。PDW仅在第1天有统计学意义（p=0.031），而在II组和III组中不显著。结论MPV,PDW,PCT随着血小板计数的减少而增加，而PI增加。这些血小板指数可用于预测血小板减少症的严重程度和登革热的严重程度。随着MPV和PDW，PCT可用于评估疾病进展的严重程度。
