PDF(Pubmed)
Abstract：
Functional seizures (FS), the most common subtype of functional neurological disorder (FND), cause serious neurological disability and significantly impact quality of life. Characterized by episodic disturbances of functioning that resemble epileptic seizures, FS coincide with multiple comorbidities and are treated poorly by existing approaches. Novel treatment approaches are sorely needed. Notably, mounting evidence supports the safety and efficacy of psychedelic-assisted therapy (PAT) for several psychiatric conditions, motivating investigations into whether this efficacy also extends to neurological disorders. Here, we synthesize past empirical findings and frameworks to construct a biopsychosocial mechanistic argument for the potential of PAT as a treatment for FS. In doing so, we highlight FS as a well-defined cohort to further understand the large-scale neural mechanisms underpinning PAT. Our synthesis is guided by a complexity science perspective which we contend can afford unique mechanistic insight into both FS and PAT, as well as help bridge these two domains. We also leverage this perspective to propose a novel analytic roadmap to identify markers of FS diagnostic specificity and treatment success. This endeavor continues the effort to bridge clinical neurology with psychedelic medicine and helps pave the way for a new field of psychedelic neurology.
摘要：
功能性癫痫发作（FS），最常见的功能性神经障碍（FND）亚型，导致严重的神经系统残疾并显著影响生活质量。以类似于癫痫发作的偶发性功能障碍为特征，FS与多种合并症同时发生，现有方法治疗效果不佳。非常需要新的治疗方法。值得注意的是,越来越多的证据支持迷幻辅助治疗（PAT）对几种精神疾病的安全性和有效性，促使研究这种疗效是否也扩展到神经系统疾病。这里,我们综合过去的实证研究结果和框架,为PAT治疗FS的潜力构建一个生物心理社会机制论证.在这样做的时候，我们强调FS是一个明确定义的队列,以进一步了解支持PAT的大规模神经机制.我们的综合是以复杂性科学观点为指导的，我们认为这可以提供对FS和PAT的独特机械见解，以及帮助桥接这两个领域。我们还利用这一观点提出了一种新的分析路线图，以识别FS诊断特异性和治疗成功的标志物。这项努力继续努力将临床神经病学与迷幻药物联系起来，并为迷幻神经病学的新领域铺平道路。
