Abstract：
OBJECTIVE: This study evaluated the tear film stability in patients with symptoms of dry eye after installation of dual polymer hydroxypropyl guar/sodium hyaluronate (DPHG/SH) vs single polymer SH.
METHODS: Patients with recently diagnosed mild to moderate dry eye disease (OSDI score 23-32 points) were included. For each patient, the right eye was randomized to receive DPHG/SH or 0.15% SH. Just after the administration of the drop to the right eye, the fellow eye received the other eye drop. The first non-invasive Keratograph first break-up time (NIKBUT), average NIKBUT and tear meniscus height (TMH) were measured before administration of the eye drops, at 1-min, 15 min, 30 min, 60 min, 90 min, and 120 min after instillation.
RESULTS: A total of 29 patients aged 22.8 ± 2.2 years participated in the study (21 women). No differences between the eye receiving DPHG/SH and single polymer SH were observed for the first NIKBUT (p = 0.45) and average NIKBUT (p = 0.24) variables at any time point. Both DPHG/SH and single polymer SH increased the TMH (p of time effect < 0.001), but with no difference between groups (p = 0.95).
CONCLUSIONS: Both DPHG/SH and single polymer SH solutions provide lubrication of the eye surface, however, with no difference in NIKBUT and TMH evaluations for up to two hours following administration.
METHODS: Patients with recently diagnosed mild to moderate dry eye disease (OSDI score 23-32 points) were included. For each patient, the right eye was randomized to receive DPHG/SH or 0.15% SH. Just after the administration of the drop to the right eye, the fellow eye received the other eye drop. The first non-invasive Keratograph first break-up time (NIKBUT), average NIKBUT and tear meniscus height (TMH) were measured before administration of the eye drops, at 1-min, 15 min, 30 min, 60 min, 90 min, and 120 min after instillation.
RESULTS: A total of 29 patients aged 22.8 ± 2.2 years participated in the study (21 women). No differences between the eye receiving DPHG/SH and single polymer SH were observed for the first NIKBUT (p = 0.45) and average NIKBUT (p = 0.24) variables at any time point. Both DPHG/SH and single polymer SH increased the TMH (p of time effect < 0.001), but with no difference between groups (p = 0.95).
CONCLUSIONS: Both DPHG/SH and single polymer SH solutions provide lubrication of the eye surface, however, with no difference in NIKBUT and TMH evaluations for up to two hours following administration.
摘要：
目的：本研究评估了在安装双聚合物羟丙基瓜尔胶/透明质酸钠（DPHG/SH）与单聚合物SH后，有干眼症状的患者的泪膜稳定性。
方法：纳入最近诊断为轻度至中度干眼症（OSDI评分23-32分）的患者。对于每个病人来说,右眼随机接受DPHG/SH或0.15%SH.就在滴到右眼后，对方的眼睛收到了另一个眼药水。第一次非侵入性角膜造影第一次分手时间（NIKBUT），在滴眼剂给药前测量平均NIKBUT和泪液半月板高度（TMH），在1分钟，15分钟,30分钟,60分钟,90分钟,滴注后120分钟。
结果：共有29名年龄为22.8±2.2岁的患者参与了研究（21名女性）。在任何时间点,对于第一NIKBUT(p=0.45)和平均NIKBUT(p=0.24)变量,未观察到眼睛接受DPHG/SH和单一聚合物SH之间的差异。DPHG/SH和单一聚合物SH都增加了TMH（时间效应p<0.001），但组间无差异(p=0.95)。
结论：DPHG/SH和单一聚合物SH溶液均可润滑眼睛表面，然而,在给药后两个小时内，NIKBUT和TMH评估没有差异。
方法：纳入最近诊断为轻度至中度干眼症（OSDI评分23-32分）的患者。对于每个病人来说,右眼随机接受DPHG/SH或0.15%SH.就在滴到右眼后，对方的眼睛收到了另一个眼药水。第一次非侵入性角膜造影第一次分手时间（NIKBUT），在滴眼剂给药前测量平均NIKBUT和泪液半月板高度（TMH），在1分钟，15分钟,30分钟,60分钟,90分钟,滴注后120分钟。
结果：共有29名年龄为22.8±2.2岁的患者参与了研究（21名女性）。在任何时间点,对于第一NIKBUT(p=0.45)和平均NIKBUT(p=0.24)变量,未观察到眼睛接受DPHG/SH和单一聚合物SH之间的差异。DPHG/SH和单一聚合物SH都增加了TMH（时间效应p<0.001），但组间无差异(p=0.95)。
结论：DPHG/SH和单一聚合物SH溶液均可润滑眼睛表面，然而,在给药后两个小时内，NIKBUT和TMH评估没有差异。
