PDF(Pubmed)
Abstract：
Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.
摘要：
具有非特殊类型的混合浸润性乳腺癌（IBC-NST）和浸润性小叶癌（ILC）组织学的原发性肿瘤在所有乳腺癌患者中约有5％存在，并且在转移水平上研究不足。这里,我们对死后组织捐献计划UPTIDER(NCT04531696)的两名原发性混合IBC-NST/ILC患者的转移瘤组织学进行了表征.尸检时收集的14和43个转移性病变的形态学特征和E-cadherin染色模式与纯ILC一致。虽然我们的发现还需要进一步验证，它们可能会挑战这些患者当前的临床实践和影像学检查方法.
