%0 Journal Article
%T Metastases of primary mixed no-special type and lobular breast cancer display an exclusive lobular histology.
%A Zels G
%A Van Baelen K
%A De Schepper M
%A Borremans K
%A Geukens T
%A Isnaldi E
%A Izci H
%A Leduc S
%A Mahdami A
%A Maetens M
%A Nguyen HL
%A Pabba A
%A Richard F
%A Van Cauwenberge J
%A Smeets A
%A Nevelsteen I
%A Neven P
%A Wildiers H
%A Van Den Bogaert W
%A Floris G
%A Desmedt C
%J Breast
%V 75
%N 0
%D 2024 Jun 12
%M 38653060
%F 4.254
%R 10.1016/j.breast.2024.103732
%X Primary tumors with a mixed invasive breast carcinoma of no-special type (IBC-NST) and invasive lobular cancer (ILC) histology are present in approximately five percent of all patients with breast cancer and are understudied at the metastatic level. Here, we characterized the histology of metastases from two patients with primary mixed IBC-NST/ILC from the postmortem tissue donation program UPTIDER (NCT04531696). The 14 and 43 metastatic lesions collected at autopsy had morphological features and E-cadherin staining patterns consistent with pure ILC. While our findings still require further validation, they may challenge current clinical practice and imaging modalities used in these patients.