PDF(Pubmed)
Abstract：
UNASSIGNED: To explore the relationship between obstructive sleep apnea (OSA) and hypoperfusion during ultra-early acute cerebral infarction.
UNASSIGNED: Data were retrospectively collected from patients admitted to our hospital with acute cerebral infarction between January 2020 and January 2022, who underwent comprehensive whole-brain computed tomography perfusion imaging and angiography examinations within 6 h of onset. The F-stroke software automatically assessed and obtained relevant data (Tmax). The patients underwent an initial screening for sleep apnea. Based on their Apnea-Hypopnea Index (AHI), patients were categorized into an AHI ≤15 (n = 22) or AHI >15 (n = 25) group. The pairwise difference of the time-to-maximum of the residue function (Tmax) > 6 s volume was compared, and the correlation between AHI, mean pulse oxygen saturation (SpO2), oxygen desaturation index (ODI), percentage of time with oxygen saturation < 90% (T90%), and the Tmax >6 s volume was analyzed.
UNASSIGNED: The Tmax >6 s volume in the AHI > 15 group was significantly larger than that in the AHI ≤ 15 group [109 (62-157) vs. 59 (21-106) mL, p = 0.013]. Spearman\'s correlation analysis revealed Tmax >6 s volume was significantly correlated with AHI, mean SpO2, ODI, and T90% in the AHI > 15 group, however, no significant correlations were observed in the AHI ≤ 15 group. Controlling for the site of occlusion and Multiphase CT angiography (mCTA) score, AHI (β = 0.919, p < 0.001), mean SpO2 (β = -0.460, p = 0.031), ODI (β = 0.467, p = 0.032), and T90% (β =0.478, p = 0.026) remained associated with early hypoperfusion in the AHI > 15 group.
UNASSIGNED: In patients with acute cerebral infarction and AHI > 15, AHI, mean SpO2, ODI and T90% were associated with early hypoperfusion. However, no such relationship exists among patients with AHI ≤ 15.
UNASSIGNED: Data were retrospectively collected from patients admitted to our hospital with acute cerebral infarction between January 2020 and January 2022, who underwent comprehensive whole-brain computed tomography perfusion imaging and angiography examinations within 6 h of onset. The F-stroke software automatically assessed and obtained relevant data (Tmax). The patients underwent an initial screening for sleep apnea. Based on their Apnea-Hypopnea Index (AHI), patients were categorized into an AHI ≤15 (n = 22) or AHI >15 (n = 25) group. The pairwise difference of the time-to-maximum of the residue function (Tmax) > 6 s volume was compared, and the correlation between AHI, mean pulse oxygen saturation (SpO2), oxygen desaturation index (ODI), percentage of time with oxygen saturation < 90% (T90%), and the Tmax >6 s volume was analyzed.
UNASSIGNED: The Tmax >6 s volume in the AHI > 15 group was significantly larger than that in the AHI ≤ 15 group [109 (62-157) vs. 59 (21-106) mL, p = 0.013]. Spearman\'s correlation analysis revealed Tmax >6 s volume was significantly correlated with AHI, mean SpO2, ODI, and T90% in the AHI > 15 group, however, no significant correlations were observed in the AHI ≤ 15 group. Controlling for the site of occlusion and Multiphase CT angiography (mCTA) score, AHI (β = 0.919, p < 0.001), mean SpO2 (β = -0.460, p = 0.031), ODI (β = 0.467, p = 0.032), and T90% (β =0.478, p = 0.026) remained associated with early hypoperfusion in the AHI > 15 group.
UNASSIGNED: In patients with acute cerebral infarction and AHI > 15, AHI, mean SpO2, ODI and T90% were associated with early hypoperfusion. However, no such relationship exists among patients with AHI ≤ 15.
摘要：
■探讨超早期急性脑梗死患者阻塞性睡眠呼吸暂停(OSA)与低灌注的关系。
■回顾性收集了2020年1月至2022年1月我院收治的急性脑梗死患者的数据，这些患者在发病6h内接受了全面的全脑CT灌注成像和血管造影检查。F-stroke软件自动评估并获得相关数据(Tmax)。患者接受了睡眠呼吸暂停的初步筛查。根据他们的呼吸暂停-呼吸不足指数(AHI)，患者分为AHI≤15(n=22)或AHI>15(n=25)组.比较了剩余函数的最大时间（Tmax）>6s体积的成对差异，以及AHI之间的相关性，平均脉搏氧饱和度（SpO2），氧饱和度指数(ODI),氧饱和度<90%的时间百分比(T90%),并分析了Tmax>6s的体积。
■AHI>15组的Tmax>6s体积明显大于AHI≤15组[109（62-157）与59(21-106)mL,p=0.013]。Spearman相关分析显示Tmax>6s体积与AHI显著相关,平均SpO2，ODI，AHI>15组的T90%，然而,在AHI≤15组中没有观察到显著的相关性.控制闭塞部位和多相CT血管造影（mCTA）评分，AHI（β=0.919，p<0.001），平均SpO2（β=-0.460，p=0.031），ODI（β=0.467，p=0.032），在AHI>15组中，T90%(β=0.478，p=0.026)与早期低灌注相关。
■在急性脑梗死患者中，AHI>15，平均SpO2、ODI和T90%与早期灌注不足相关。然而,AHI≤15的患者之间不存在这种关系.
■回顾性收集了2020年1月至2022年1月我院收治的急性脑梗死患者的数据，这些患者在发病6h内接受了全面的全脑CT灌注成像和血管造影检查。F-stroke软件自动评估并获得相关数据(Tmax)。患者接受了睡眠呼吸暂停的初步筛查。根据他们的呼吸暂停-呼吸不足指数(AHI)，患者分为AHI≤15(n=22)或AHI>15(n=25)组.比较了剩余函数的最大时间（Tmax）>6s体积的成对差异，以及AHI之间的相关性，平均脉搏氧饱和度（SpO2），氧饱和度指数(ODI),氧饱和度<90%的时间百分比(T90%),并分析了Tmax>6s的体积。
■AHI>15组的Tmax>6s体积明显大于AHI≤15组[109（62-157）与59(21-106)mL,p=0.013]。Spearman相关分析显示Tmax>6s体积与AHI显著相关,平均SpO2，ODI，AHI>15组的T90%，然而,在AHI≤15组中没有观察到显著的相关性.控制闭塞部位和多相CT血管造影（mCTA）评分，AHI（β=0.919，p<0.001），平均SpO2（β=-0.460，p=0.031），ODI（β=0.467，p=0.032），在AHI>15组中，T90%(β=0.478，p=0.026)与早期低灌注相关。
■在急性脑梗死患者中，AHI>15，平均SpO2、ODI和T90%与早期灌注不足相关。然而,AHI≤15的患者之间不存在这种关系.
