PDF(Pubmed)
Abstract：
Salivary stones, known as sialoliths, form within the salivary ducts due to abnormal salivary composition and cause painful symptoms, for which surgical removal is the primary treatment. This study explored the role of the salivary microbial communities in the formation of sialoliths. We conducted a comparative analysis of microbial communities present in the saliva and salivary stones, and sequenced the 16S rRNA gene in samples obtained from patients with sialoliths and from healthy individuals. Although the diversity in the saliva was high, the essential features of the microbial environment in sialoliths were low diversity and evenness. The association of microbial abundance between stones and saliva revealed a positive correlation between Peptostreptococcus and Porphyromonas, and a negative correlation for Pseudomonas in saliva. The functional potential differences between saliva and stones Bacterial chemotaxis and the citrate cycle were negatively correlated with most genera found in salivary stone samples. However, the functions required for organic compound degradation did not differ between the saliva samples. Although some microbes were shared between the sialoliths and saliva, their compositions differed significantly. Our study presents a novel comparison between salivary stones and salivary microbiomes, suggesting potential preventive strategies against sialolithiasis.
摘要：
唾液结石,被称为唾液石，由于唾液成分异常而在唾液导管内形成并引起疼痛症状，手术切除是主要治疗方法。这项研究探讨了唾液微生物群落在唾液酸形成中的作用。我们对唾液和唾液结石中存在的微生物群落进行了比较分析，并对从具有唾液酸的患者和健康个体获得的样品中的16SrRNA基因进行了测序。虽然唾液的多样性很高，硅岩中微生物环境的基本特征是低多样性和均匀性。结石和唾液之间的微生物丰度的关联揭示了肽链球菌和卟啉单胞菌之间的正相关,与唾液中的假单胞菌呈负相关。唾液和结石之间的功能电位差异细菌趋化性和柠檬酸盐周期与唾液结石样品中发现的大多数属呈负相关。然而,唾液样品之间有机化合物降解所需的功能没有差异。尽管一些微生物在唾液和唾液之间共享，它们的成分差异很大。我们的研究提出了一种新的唾液结石和唾液微生物组之间的比较，建议预防唾液酸结石的潜在策略。
