PDF(Pubmed)
Abstract：
Circadian clocks regulate metabolic homeostasis. Disruption to our circadian clocks, by lifestyle behaviors such as timing of eating and sleeping, has been linked to increased rates of metabolic disorders. There is now considerable evidence that selected dietary (poly)phenols, including flavonoids, phenolic acids and tannins, may modulate metabolic and circadian processes. This review evaluates the effects of (poly)phenols on circadian clock genes and linked metabolic homeostasis in vitro, and potential mechanisms of action, by critically evaluating the literature on mammalian cells. A systematic search was conducted to ensure full coverage of the literature and identified 43 relevant studies addressing the effects of (poly)phenols on cellular circadian processes. Nobiletin and tangeretin, found in citrus, (-)-epigallocatechin-3-gallate from green tea, urolithin A, a gut microbial metabolite from ellagitannins in fruit, curcumin, bavachalcone, cinnamic acid, and resveratrol at low micromolar concentrations all affect circadian molecular processes in multiple types of synchronized cells. Nobiletin emerges as a putative retinoic acid-related orphan receptor (RORα/γ) agonist, leading to induction of the circadian regulator brain and muscle ARNT-like 1 (BMAL1), and increased period circadian regulator 2 (PER2) amplitude and period. These effects are clear despite substantial variations in the protocols employed, and this review suggests a methodological framework to help future study design in this emerging area of research.
摘要：
代谢稳态受生物钟调节。扰乱我们的生物钟，通过生活方式，比如吃饭和睡觉的时间，与代谢紊乱的增加有关。现在有相当多的证据表明，选定的膳食(聚)酚，包括类黄酮,酚酸和单宁，可以调节代谢和昼夜节律过程。这篇综述评估了（多）酚在体外对昼夜节律基因和相关代谢稳态的影响，和潜在的作用机制，通过严格评估哺乳动物细胞的文献。进行了系统的搜索，以确保文献的全面覆盖，并确定了43项相关研究，涉及（多）酚对细胞昼夜节律过程的影响。诺比林和橘皮素，在柑橘中发现,来自绿茶的（-）-表没食子儿茶素-3-没食子酸酯，尿石素A,一种来自水果中单宁的肠道微生物代谢产物，姜黄素,bavachalcone,低微摩尔浓度的肉桂酸和白藜芦醇都会影响多种类型同步细胞的昼夜节律分子过程。Nobiletin作为一种推定的维甲酸相关孤儿受体（RORα/γ）激动剂出现，导致昼夜节律调节剂脑和肌肉ARNT-like1（BMAL1）的诱导，并增加周期昼夜节律调节器2(PER2)的振幅和周期。尽管所采用的方案有很大的不同，但这些影响还是很明显的，这篇综述提出了一个方法学框架，以帮助这一新兴研究领域的未来研究设计。
