Abstract：
UNASSIGNED: The aim of this study was to investigate the association between myopia and longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness in type 2 diabetic patients without diabetic retinopathy (DR).
UNASSIGNED: A total of 1069 participants with a median follow-up time of 1.9 years were included in this study. The participants were categorized into four groups based on the presence of myopia (≤ -0.5 diopter [D]) and diabetes without DR, including a control group (n = 412), diabetes group (n = 416), myopia group (n = 115), and diabetes + myopia group (n = 126). Peripapillary average and sectoral RNFL measurements were obtained using 6 × 6 mm swept-source optical coherence tomography (SS-OCT) scans centered at the optic disc. The change rate of pRNFL, adjusted for age and sex, was calculated and compared among the four groups to investigate the impact of myopia and diabetes.
UNASSIGNED: The baseline estimated pRNFL thickness after adjustment for covariates was 113.7 μm, 116.2 μm, 108.0 μm, and 105.6 μm in the control, diabetes, myopia, and diabetes + myopia group, respectively (diabetes > control > myopia = diabetes + myopia, p < 0.001). The respective average pRNFL loss in the four groups was -0.48 μm/year, -1.11 μm/year, -1.23 μm/year, and -2.62 μm/year (all p < 0.01). The diabetes + myopia group exhibited a greater rate of average pRNFL reduction compared to the other groups (all p < 0.001). Multivariate analysis using a linear mixed-effects model showed that age, diabetes, axial length (AL), and baseline pRNFL thickness were significantly associated with the rate of average pRNFL reduction.
UNASSIGNED: The diabetes group showed a faster rate of average pRNFL thickness reduction compared to healthy controls, regardless of the presence of myopia. The average pRNFL thickness decreased more rapidly when diabetes and myopia were present simultaneously than in the individual diabetes or myopia group. Both diabetes and myopia were associated with accelerated pRNFL loss.
UNASSIGNED: A total of 1069 participants with a median follow-up time of 1.9 years were included in this study. The participants were categorized into four groups based on the presence of myopia (≤ -0.5 diopter [D]) and diabetes without DR, including a control group (n = 412), diabetes group (n = 416), myopia group (n = 115), and diabetes + myopia group (n = 126). Peripapillary average and sectoral RNFL measurements were obtained using 6 × 6 mm swept-source optical coherence tomography (SS-OCT) scans centered at the optic disc. The change rate of pRNFL, adjusted for age and sex, was calculated and compared among the four groups to investigate the impact of myopia and diabetes.
UNASSIGNED: The baseline estimated pRNFL thickness after adjustment for covariates was 113.7 μm, 116.2 μm, 108.0 μm, and 105.6 μm in the control, diabetes, myopia, and diabetes + myopia group, respectively (diabetes > control > myopia = diabetes + myopia, p < 0.001). The respective average pRNFL loss in the four groups was -0.48 μm/year, -1.11 μm/year, -1.23 μm/year, and -2.62 μm/year (all p < 0.01). The diabetes + myopia group exhibited a greater rate of average pRNFL reduction compared to the other groups (all p < 0.001). Multivariate analysis using a linear mixed-effects model showed that age, diabetes, axial length (AL), and baseline pRNFL thickness were significantly associated with the rate of average pRNFL reduction.
UNASSIGNED: The diabetes group showed a faster rate of average pRNFL thickness reduction compared to healthy controls, regardless of the presence of myopia. The average pRNFL thickness decreased more rapidly when diabetes and myopia were present simultaneously than in the individual diabetes or myopia group. Both diabetes and myopia were associated with accelerated pRNFL loss.
摘要：
■这项研究的目的是研究近视与无糖尿病性视网膜病变（DR）的2型糖尿病患者的乳头周围视网膜神经纤维层（pRNFL）厚度纵向变化之间的关系。
■本研究纳入了1069名参与者，中位随访时间为1.9年。根据近视（≤-0.5屈光度[D]）和无DR的糖尿病的存在，将参与者分为四组。包括对照组（n=412），糖尿病组（n=416），近视组（n=115），糖尿病+近视组(n=126)。使用以视盘为中心的6×6mm扫频光源光学相干断层扫描（SS-OCT）扫描获得乳头周围平均值和部门RNFL测量值。pRNFL的变化率，根据年龄和性别调整，计算并比较四组对近视和糖尿病的影响。
■对协变量进行调整后的基线估计pRNFL厚度为113.7μm，116.2μm,108.0μm,对照中的105.6μm，糖尿病,近视,糖尿病+近视组，分别(糖尿病>控制>近视=糖尿病+近视,p<0.001)。四组的平均pRNFL损失为-0.48μm/年，-1.11μm/年,-1.23μm/年,和-2.62μm/年（所有p<0.01）。与其他组相比,糖尿病+近视组表现出更高的平均pRNFL降低率(所有p<0.001)。使用线性混合效应模型的多变量分析表明，年龄，糖尿病,轴向长度（AL），基线pRNFL厚度与平均pRNFL减少率显着相关。
■与健康对照组相比，糖尿病组显示出更快的平均pRNFL厚度减少速率，不管是否存在近视。与个体糖尿病或近视组相比，糖尿病和近视同时存在时，平均pRNFL厚度下降得更快。糖尿病和近视都与pRNFL的加速丢失有关。
■本研究纳入了1069名参与者，中位随访时间为1.9年。根据近视（≤-0.5屈光度[D]）和无DR的糖尿病的存在，将参与者分为四组。包括对照组（n=412），糖尿病组（n=416），近视组（n=115），糖尿病+近视组(n=126)。使用以视盘为中心的6×6mm扫频光源光学相干断层扫描（SS-OCT）扫描获得乳头周围平均值和部门RNFL测量值。pRNFL的变化率，根据年龄和性别调整，计算并比较四组对近视和糖尿病的影响。
■对协变量进行调整后的基线估计pRNFL厚度为113.7μm，116.2μm,108.0μm,对照中的105.6μm，糖尿病,近视,糖尿病+近视组，分别(糖尿病>控制>近视=糖尿病+近视,p<0.001)。四组的平均pRNFL损失为-0.48μm/年，-1.11μm/年,-1.23μm/年,和-2.62μm/年（所有p<0.01）。与其他组相比,糖尿病+近视组表现出更高的平均pRNFL降低率(所有p<0.001)。使用线性混合效应模型的多变量分析表明，年龄，糖尿病,轴向长度（AL），基线pRNFL厚度与平均pRNFL减少率显着相关。
■与健康对照组相比，糖尿病组显示出更快的平均pRNFL厚度减少速率，不管是否存在近视。与个体糖尿病或近视组相比，糖尿病和近视同时存在时，平均pRNFL厚度下降得更快。糖尿病和近视都与pRNFL的加速丢失有关。
