Abstract：
OBJECTIVE: The aim of this study was to investigate the association of fasting C-peptide and glucagon with diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2DM).
METHODS: A comprehensive evaluation was conducted on 797 patients with T2DM to assess the various risk factors affecting DPN. The subjects were categorized into short duration and long duration group according to the duration of diabetes with a threshold of 10 years. Logistic regression analysis was employed to examine the association between DPN and islet function, as well as other parameters. Receiver operating characteristic curve analysis was performed to evaluate the predictive capability of glucagon.
RESULTS: The fasting C-peptide levels were significantly lower in the DPN patients with short duration of diabetes, but lost significance in the long duration group. Conversely, a decreased level of glucagon was only observed in DPN patients with long duration of diabetes. For the group with long duration of diabetes, glucagon was the sole risk factor associated with DPN. The receiver operating characteristic curve analysis revealed that glucagon in the long duration group exhibited a moderate area under the curve of 0.706.
CONCLUSIONS: The serum glucagon levels in T2DM patients with DPN exhibited bidirectional changes based on the duration of diabetes. Decreased glucagon was associated with DPN in T2DM patients with long duration of diabetes.
METHODS: A comprehensive evaluation was conducted on 797 patients with T2DM to assess the various risk factors affecting DPN. The subjects were categorized into short duration and long duration group according to the duration of diabetes with a threshold of 10 years. Logistic regression analysis was employed to examine the association between DPN and islet function, as well as other parameters. Receiver operating characteristic curve analysis was performed to evaluate the predictive capability of glucagon.
RESULTS: The fasting C-peptide levels were significantly lower in the DPN patients with short duration of diabetes, but lost significance in the long duration group. Conversely, a decreased level of glucagon was only observed in DPN patients with long duration of diabetes. For the group with long duration of diabetes, glucagon was the sole risk factor associated with DPN. The receiver operating characteristic curve analysis revealed that glucagon in the long duration group exhibited a moderate area under the curve of 0.706.
CONCLUSIONS: The serum glucagon levels in T2DM patients with DPN exhibited bidirectional changes based on the duration of diabetes. Decreased glucagon was associated with DPN in T2DM patients with long duration of diabetes.
摘要：
目的：本研究旨在探讨2型糖尿病（T2DM）患者空腹C肽和胰高血糖素与糖尿病周围神经病变（DPN）的关系。
方法：对797例T2DM患者进行综合评价，以评估影响DPN的各种危险因素。根据糖尿病的持续时间，将受试者分为短期和长期组，阈值为10年。采用Logistic回归分析DPN与胰岛功能的关系。以及其他参数。进行受试者工作特征曲线分析以评估胰高血糖素的预测能力。
结果：糖尿病病程短的DPN患者空腹C肽水平明显降低，但在长期组中失去了意义。相反，胰高血糖素水平降低仅在糖尿病病程较长的DPN患者中观察到.对于长期糖尿病患者，胰高血糖素是与DPN相关的唯一危险因素。受试者工作特征曲线分析显示，长持续时间组的胰高血糖素在0.706的曲线下表现出中等面积。
结论：2型糖尿病合并DPN患者的血清胰高血糖素水平随糖尿病病程呈双向变化。胰高血糖素降低与糖尿病病程长的T2DM患者DPN相关。
方法：对797例T2DM患者进行综合评价，以评估影响DPN的各种危险因素。根据糖尿病的持续时间，将受试者分为短期和长期组，阈值为10年。采用Logistic回归分析DPN与胰岛功能的关系。以及其他参数。进行受试者工作特征曲线分析以评估胰高血糖素的预测能力。
结果：糖尿病病程短的DPN患者空腹C肽水平明显降低，但在长期组中失去了意义。相反，胰高血糖素水平降低仅在糖尿病病程较长的DPN患者中观察到.对于长期糖尿病患者，胰高血糖素是与DPN相关的唯一危险因素。受试者工作特征曲线分析显示，长持续时间组的胰高血糖素在0.706的曲线下表现出中等面积。
结论：2型糖尿病合并DPN患者的血清胰高血糖素水平随糖尿病病程呈双向变化。胰高血糖素降低与糖尿病病程长的T2DM患者DPN相关。
