关键词: cancer nanotheranostics personalized medicine radiotheranostics synthetic biology

Mesh : Humans Neoplasms / therapy diagnosis Theranostic Nanomedicine / methods Precision Medicine / methods Drug Delivery Systems / methods Nanomedicine / methods History, 20th Century Animals History, 21st Century

来  源:   DOI:10.7150/thno.96675   PDF(Pubmed)

Abstract:
Cancer has remained a formidable challenge in medicine and has claimed an enormous number of lives worldwide. Theranostics, combining diagnostic methods with personalized therapeutic approaches, shows huge potential to advance the battle against cancer. This review aims to provide an overview of theranostics in oncology: exploring its history, current advances, challenges, and prospects. We present the fundamental evolution of theranostics from radiotherapeutics, cellular therapeutics, and nanotherapeutics, showcasing critical milestones in the last decade. From the early concept of targeted drug delivery to the emergence of personalized medicine, theranostics has benefited from advances in imaging technologies, molecular biology, and nanomedicine. Furthermore, we emphasize pertinent illustrations showcasing that revolutionary strategies in cancer management enhance diagnostic accuracy and provide targeted therapies customized for individual patients, thereby facilitating the implementation of personalized medicine. Finally, we describe future perspectives on current challenges, emerging topics, and advances in the field.
摘要:
癌症仍然是医学上的一个巨大挑战,并在全世界夺走了大量的生命。Theranostics,将诊断方法与个性化治疗方法相结合,显示出推进对抗癌症的巨大潜力。这篇综述旨在提供肿瘤学的概述:探索其历史,目前的进展,挑战,和前景。我们介绍了放射疗法的基本演变,细胞疗法,和纳米疗法,展示过去十年的重要里程碑。从早期的靶向给药概念到个性化医疗的出现,theranosics受益于成像技术的进步,分子生物学,和纳米医学。此外,我们强调了相关的插图,展示了癌症管理中的革命性策略提高了诊断准确性,并为个体患者提供了定制的靶向治疗,从而促进个性化医疗的实施。最后,我们描述了对当前挑战的未来观点,新兴主题,和在该领域的进步。
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