PDF(Pubmed)
Abstract：
Lung cancer is the most common cancer in the world due to its high incidence and recurrence. Genetic instability is one of the main factors leading to its occurrence, development and poor prognosis. Decreased xeroderma pigmentosum group C (XPC) expression notably enhances the stem cell properties of lung cancer cells and increases their proliferation and migration. Additionally, patients with lung cancer and low XPC expression had a poor prognosis. The purpose of the present study was to analyze the effect of XPC and IFN-γ on the clinical prognosis of patients with non-small cell lung cancer (NSCLC). Lung adenocarcinoma specimens were collected from a total of 140 patients with NSCLC. Additionally, from these 140 patients, 48 paracarcinoma tissue specimens were also collected, which were later used to construct tissue microarrays. The expression of XPC and IFN-γ in cancer tissues and in paraneoplastic tissues was detected using immunohistochemistry. The prognosis and overall survival of patients were determined through telephone follow-up. The results showed a positive correlation between expression of XPC and IFN-γ in NSCLC. Additionally, high expression of both markers was associated with a favorable prognosis in patients with NSCLC. The aforementioned findings suggest that the expression of XPC and IFN-γ has prognostic value in clinical practice and is expected to become a marker for clinical application.
摘要：
肺癌是世界上最常见的癌症，因其发病率和复发率高。遗传不稳定性是导致其发生的主要因素之一,发展和预后不良。着色性干皮病C组（XPC）表达的降低显着增强了肺癌细胞的干细胞特性，并增加了其增殖和迁移。此外,XPC低表达的肺癌患者预后不良.本研究的目的是分析XPC和IFN-γ对非小细胞肺癌（NSCLC）患者临床预后的影响。从总共140例NSCLC患者中收集肺腺癌标本。此外,从这140名患者中，还收集了48个癌旁组织标本，后来被用来构建组织微阵列。用免疫组织化学方法检测XPC和IFN-γ在癌组织和副肿瘤组织中的表达。通过电话随访确定患者的预后和总生存期。结果NSCLC中XPC和IFN-γ的表达呈正相关。此外,两种标志物的高表达与NSCLC患者的良好预后相关.上述发现提示XPC和IFN-γ的表达在临床实践中具有预后价值,并有望成为临床应用的标志物。
