Abstract：
Reversible S-acylation plays a pivotal role in various biological processes, modulating protein functions such as subcellular localization, protein stability/activity, and protein-protein interactions. These modifications are mediated by acyltransferases and deacylases, among which the most abundant modification is S-palmitoylation. Growing evidence has shown that this rivalrous pair of modifications, occurring in a reversible cycle, is essential for various biological functions. Aberrations in this process have been associated with various diseases, including cancer, neurological disorders, and immune diseases. This underscores the importance of studying enzymes involved in acylation and deacylation to gain further insights into disease pathogenesis and provide novel strategies for disease treatment. In this Review, we summarize our current understanding of the structure and physiological function of deacylases, highlighting their pivotal roles in pathology. Our aim is to provide insights for further clinical applications.
摘要：
可逆的S-酰化在各种生物过程中起着举足轻重的作用,调节蛋白质功能，如亚细胞定位，蛋白质稳定性/活性，和蛋白质-蛋白质相互作用。这些修饰是由酰基转移酶和脱酰酶介导的，其中最丰富的修饰是S-棕榈酰化。越来越多的证据表明，这对竞争的修改，发生在可逆循环中，对各种生物功能至关重要。这个过程中的畸变与各种疾病有关，包括癌症,神经系统疾病,和免疫疾病。这强调了研究与酰化和脱酰化有关的酶以进一步了解疾病发病机理并为疾病治疗提供新策略的重要性。在这篇评论中,我们总结了我们目前对脱酰酶的结构和生理功能的理解，突出它们在病理学中的关键作用。我们的目标是为进一步的临床应用提供见解。
