PDF(Pubmed)
Abstract：
To investigate the association between serum neurofilament light chain (NfL) levels, inflammatory cytokines, and cognitive function to assess their utility in the early detection of mild cognitive impairment (MCI). We conducted a cross-sectional study involving 157 community-dwelling individuals aged 55 years and above, categorized into healthy controls, MCI, and probable Alzheimer\'s disease (AD). Serum levels of NfL, inflammatory cytokines, and AD pathology markers were measured using enzyme-linked immunosorbent assay (ELISA). Correlations between these biomarkers and cognitive function were analyzed, and the diagnostic performance of the cognitive assessment scales and serum biomarker concentrations was evaluated using receiver operating characteristic (ROC) curve analysis. Serum NfL levels were significantly elevated in MCI and probable AD groups compared to healthy controls. Positive correlations were found between serum NfL and inflammatory cytokines IL-1β, IL-6, and Aβ40. Combining serum NfL with p-tau217 and the Boston Naming Test significantly enhanced the predictive accuracy for MCI. However, combining serum NfL with inflammatory markers did not improve MCI prediction accuracy. Elevated serum NfL is associated with cognitive impairment and inflammatory markers, suggesting its potential as a peripheral serum biomarker for MCI detection. The combination of serum NfL with p-tau217 and cognitive tests could offer a more accurate prediction of MCI, providing new insights for AD treatment strategies.
摘要：
探讨血清神经丝轻链(NfL)水平与血清神经丝轻链(NfL)水平的关系,炎性细胞因子，和认知功能，以评估其在早期发现轻度认知障碍（MCI）中的效用。我们进行了一项横断面研究，涉及157名55岁及以上的社区居民，分类为健康对照，MCI和可能的阿尔茨海默病（AD）。血清NfL水平，炎性细胞因子，采用酶联免疫吸附试验(ELISA)检测AD病理指标。分析这些生物标志物与认知功能的相关性,使用受试者工作特征(ROC)曲线分析评估认知评估量表和血清生物标志物浓度的诊断性能。与健康对照组相比，MCI和可能的AD组的血清NfL水平显着升高。血清NfL与炎症因子IL-1β呈正相关,IL-6和Aβ40。血清NfL与p-tau217和波士顿命名测试的结合显着提高了MCI的预测准确性。然而,血清NfL与炎症标志物的结合并不能提高MCI预测的准确性。血清NfL升高与认知障碍和炎症标志物相关，提示其作为MCI检测的外周血清生物标志物的潜力。血清NfL与p-tau217和认知测试的组合可以提供更准确的MCI预测，为AD治疗策略提供新的见解。
