Abstract：
Dose conformity is an essential parameter used in radiotherapy and radiosurgery that measures the correspondence of the dose distribution derived from a Treatment Planning System (TPS) with the actual volume to be treated, the Planning Treatment Volume (PTV). The present work uses a method based on the expansion of dose distributions and PTVs by three-dimensional Zernike polynomials and further comparison of their moments to define a general criterion of dose conformity. To carry on this study, data coming from 20 patients comprising 80 datasets exported from the TPS, which included imaging data (PTVs) and dose distributions corresponding to different treatment modalities: three-dimensional conformal radiotherapy, intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT), were used. The expansions in Zernike polynomials were obtained up to order 6 and reconstructed dose distributions and PTVs were obtained and compared, and several definitions for a general dose conformity index were proposed. Results indicate agreement between the proposed dose conformity index and the Conformation Number CN. The proposed method allows for a systematic approach to the analysis of dose distributions with further extensions in AI applications.
摘要：
剂量一致性是放射治疗和放射外科中使用的重要参数，用于测量从治疗计划系统（TPS）得出的剂量分布与要治疗的实际体积的对应关系。计划治疗量（PTV）。本工作使用一种基于通过三维Zernike多项式扩展剂量分布和PTV的方法，并进一步比较它们的矩，以定义剂量一致性的一般标准。为了进行这项研究，数据来自20名患者，包括从TPS导出的80个数据集，其中包括成像数据（PTV）和对应于不同治疗方式的剂量分布：三维适形放射治疗，调强放射治疗（IMRT）和体积调强治疗（VMAT），被使用。获得Zernike多项式的展开式达到6阶，并获得并比较了重建的剂量分布和PTV，并提出了一般剂量一致性指数的几种定义。结果表明，建议的剂量一致性指数与构象数CN一致。所提出的方法允许采用系统的方法来分析剂量分布，并在AI应用中进一步扩展。
