Abstract：
Central and peripheral giant cell granulomas are benign entities mostly seen in mandibular anterior region at female individuals, usually with observed recurrence. Their etiology is still unclear, as is the optimal method for treating them. The aim of this study was to evaluate the incidence, treatment methods, recurrence rates, and initial and definitive correlation of central and peripheral giant cell granulomas. Patients who were referred to our clinic between 2013 and 2023 and who had the lesions\' definitive diagnosis as \"central giant cell granuloma\" (CGCG) or \"peripheral giant cell granuloma\" (PGCG) were included in the study. Demographic data, recurrence rates, treatment methods, lesion location, clinical behaviors, and sizes were noted on the reports. A total of 30 lesions in 23 patients (14 PGCG and 9 CGCG) were evaluated in this study. The mean follow-up time was 62.6 months; 8 of 23 patients had systemic disease. While only 1 patient was observed to have cortical bone destruction in PCGC, all patients were found to have cortical bone destruction in CGCG (p < 0.05). In both lesions, the correlation of preliminary and definitive diagnosis was evaluated, and it was found to be 50% in PGCG while it was 77.7% in CGCG. The recurrence rates were 21.4% in PGCG and 33.3% in CGCG. Curettage was applied in all patients. Additional treatments (intralesional steroid injections, denasumab applications, resection, and graft application) were performed in 5 patients who were found to have CGCG (p = 0.004). However, there was no significant relation between treatment method and recurrence in CGCG (p > 0.05). Various peripheral lesions could mimic PGCG; thus, curettage therapy could be appropriate in the treatment of PGCG. Nevertheless, in some cases of CGCG, additional treatment methods could be more effective for preventing recurrence and any other complications.
摘要：
中央和周围巨细胞肉芽肿是良性实体，主要见于女性的下颌前区。通常观察到复发。其病因尚不清楚,治疗它们的最佳方法也是如此。这项研究的目的是评估发病率，治疗方法,复发率,中央和周围巨细胞肉芽肿的初步和明确的相关性。在2013年至2023年期间转诊至我们诊所并具有明确诊断为“中央性巨细胞肉芽肿”（CGCG）或“周围性巨细胞肉芽肿”（PGCG）的患者纳入研究。人口统计数据,复发率,治疗方法,病变位置,临床行为，报告中注明了大小。在这项研究中，对23例患者（14例PGCG和9例CGCG）中的30个病变进行了评估。平均随访时间为62.6个月；23例患者中有8例患有全身性疾病。虽然只有1例患者在PCGC中观察到皮质骨破坏，所有患者均发现CGCG中皮质骨破坏（p<0.05）。在这两个病变中，评估了初步和最终诊断的相关性，PGCG中的比例为50％，CGCG中的比例为77.7％。PGCG和CGCG的复发率分别为21.4%和33.3%。所有患者均采用刮宫术。额外的治疗（病灶内注射类固醇，denasumab应用，切除,和移植物应用）在5例发现CGCG的患者中进行（p=0.004）。然而,CGCG的治疗方法与复发无明显关系（p>0.05）。各种外周病变可以模拟PGCG；因此，在PGCG的治疗中，刮宫疗法可能是合适的。然而，在CGCG的某些情况下，额外的治疗方法可能更有效地预防复发和任何其他并发症.
