Abstract：
OBJECTIVE: Limited data exist on the association between physical activity (PA) and depression in older adults from low- and middle-income countries (LMICs). In this study, we examine the association between meeting the World Health Organization (WHO) PA guidelines and depression in adults aged ≥50 years in Ghana and investigate the psychosomatic factors explaining this association.
METHODS: Cross-sectional data from the Aging, Health, Psychological Well-being, and Health-seeking Behavior Study in Ghana (2016-18) were analyzed. Depression was assessed with the Center for Epidemiological Studies Depression Scale (CES-D-10). PA was assessed using the International Physical Activity Questionnaire Short Form (IPAQ-SF). Multivariable logistic regression and Hayes PROCESS macro with bootstrapping mediation analyses were performed to evaluate the hypothesized associations.
RESULTS: The study included 1201 individuals (mean [SD] age 66.1 [11.9] years; 63.3% women). The prevalence of meeting PA guidelines and depression was 36.7% and 29.5%, respectively. Meeting the WHO-recommended PA guidelines was associated with a 16% lower rate of developing depression even after adjusting for potential confounders (OR = 0.84, p <0.001). This association was much stronger among men and those aged 50-64 years. Loneliness, social isolation, sleep problems, functional limitations, and pain characteristics largely mediated the association of PA with depression.
CONCLUSIONS: PA was negatively associated with depression among older adults in Ghana, and psychosocial and physical factors partially explained the association. The promotion of PA in old age may aid in the prevention of depression, especially in men and those aged 50-64 years. Longitudinal data may confirm our findings.
METHODS: Cross-sectional data from the Aging, Health, Psychological Well-being, and Health-seeking Behavior Study in Ghana (2016-18) were analyzed. Depression was assessed with the Center for Epidemiological Studies Depression Scale (CES-D-10). PA was assessed using the International Physical Activity Questionnaire Short Form (IPAQ-SF). Multivariable logistic regression and Hayes PROCESS macro with bootstrapping mediation analyses were performed to evaluate the hypothesized associations.
RESULTS: The study included 1201 individuals (mean [SD] age 66.1 [11.9] years; 63.3% women). The prevalence of meeting PA guidelines and depression was 36.7% and 29.5%, respectively. Meeting the WHO-recommended PA guidelines was associated with a 16% lower rate of developing depression even after adjusting for potential confounders (OR = 0.84, p <0.001). This association was much stronger among men and those aged 50-64 years. Loneliness, social isolation, sleep problems, functional limitations, and pain characteristics largely mediated the association of PA with depression.
CONCLUSIONS: PA was negatively associated with depression among older adults in Ghana, and psychosocial and physical factors partially explained the association. The promotion of PA in old age may aid in the prevention of depression, especially in men and those aged 50-64 years. Longitudinal data may confirm our findings.
摘要：
目标：关于低收入和中等收入国家（LMICs）的老年人体力活动（PA）与抑郁之间关系的数据有限。在这项研究中,我们研究了加纳符合世界卫生组织(WHO)PA指南与≥50岁成人抑郁之间的关联,并调查了解释这种关联的心身因素.
方法：来自老龄化的横截面数据，健康,心理健康,和加纳寻求健康行为研究(2016-18)进行了分析。使用流行病学研究中心抑郁量表（CES-D-10）评估抑郁症。使用国际身体活动问卷简表（IPAQ-SF）评估PA。进行了多变量逻辑回归和HayesPROCESS宏以及自举中介分析以评估假设的关联。
结果：该研究包括1201名个体（平均[SD]年龄66.1[11.9]岁；63.3％的女性）。符合PA指南和抑郁症的患病率分别为36.7％和29.5％，分别。即使在调整了潜在的混杂因素后，符合WHO推荐的PA指南与抑郁症的发生率降低了16％（OR=0.84，p<0.001）。这种关联在男性和50-64岁的人群中更强。孤独,社会孤立,睡眠问题,功能限制，疼痛特征在很大程度上介导了PA与抑郁症的关联。
结论：PA与加纳老年人的抑郁症呈负相关，心理社会和身体因素部分解释了这种联系。在老年推广PA可能有助于预防抑郁症，尤其是男性和50-64岁的人。纵向数据可以证实我们的发现。
方法：来自老龄化的横截面数据，健康,心理健康,和加纳寻求健康行为研究(2016-18)进行了分析。使用流行病学研究中心抑郁量表（CES-D-10）评估抑郁症。使用国际身体活动问卷简表（IPAQ-SF）评估PA。进行了多变量逻辑回归和HayesPROCESS宏以及自举中介分析以评估假设的关联。
结果：该研究包括1201名个体（平均[SD]年龄66.1[11.9]岁；63.3％的女性）。符合PA指南和抑郁症的患病率分别为36.7％和29.5％，分别。即使在调整了潜在的混杂因素后，符合WHO推荐的PA指南与抑郁症的发生率降低了16％（OR=0.84，p<0.001）。这种关联在男性和50-64岁的人群中更强。孤独,社会孤立,睡眠问题,功能限制，疼痛特征在很大程度上介导了PA与抑郁症的关联。
结论：PA与加纳老年人的抑郁症呈负相关，心理社会和身体因素部分解释了这种联系。在老年推广PA可能有助于预防抑郁症，尤其是男性和50-64岁的人。纵向数据可以证实我们的发现。
