METHODS: Using data from the OIT (Origins of Infant Temperament) study, which includes deep phenotyping of infant temperament, we identified parent-report measures that were associated with observed novelty-evoked distress. These parent-report measures were then summarized into a composite score used for imaging analysis. Our infant magnetic resonance imaging sample was a synthetic cohort, harmonizing data from 2 functional magnetic resonance imaging studies of 4-month-old infants (OIT and BCP [Baby Connectome Project]; n = 101), both of which included measures of parent-reported temperament. Brain-behavior associations were evaluated using enrichment, a statistical approach that quantifies the clustering of brain-behavior associations within network pairs.
RESULTS: Results demonstrated that parent-report composites of novelty-evoked distress were significantly associated with 3 network pairs: dorsal attention-salience/ventral attention, dorsal attention-default mode, and dorsal attention-control. These network pairs demonstrated negative associations with novelty-evoked distress, indicating that less connectivity between these network pairs was associated with greater novelty-evoked distress. Additional analyses demonstrated that dorsal attention-control network connectivity was associated with observed novelty-evoked distress in the OIT sample (n = 38).
CONCLUSIONS: Overall, this work is broadly consistent with existing work and implicates dorsal attention network connectivity in novelty-evoked distress. This study provides novel data on the neural basis of infant novelty-evoked distress.
方法:使用来自婴儿气质起源(OIT)研究的数据,其中包括婴儿气质的深层表型,我们确定了与观察到的新奇诱发的窘迫相关的家长报告指标.然后将这些家长报告测量结果汇总为用于成像分析的综合评分。我们的婴儿MRI样本是“合成队列”,对来自4个月大婴儿(OIT和BabyConnectomeProject[BCP];n=101)的两项fMRI研究的数据进行协调,这两项研究均包括父母报告的气质。使用“富集,“一种统计方法,可以量化网络对中大脑行为关联的聚类。
结果:结果表明,新颖性诱发的困扰的父母报告复合与三个网络对显著相关:背侧注意力-显著性/腹侧注意力,背部注意-默认,和背部注意力控制。这些网络对表现出与新颖性引起的困扰的负相关,这表明这些网络对之间的连通性较低与新颖性引起的困扰更大相关。其他分析表明,在OIT样本中(n=38),背侧注意力控制网络连接与观察到的新颖性诱发的困扰有关。
结论:总体而言,这项工作与现有工作基本一致,并暗示了新颖性诱发的窘迫中的背侧注意力网络连接。这项研究提供了有关婴儿新奇引起的困扰的神经基础的新数据。