PDF(Pubmed)
Abstract：
BACKGROUND: Observational assessments of infant temperament have provided unparalleled insight into prediction of risk for social anxiety. However, it is challenging to administer and score these assessments alongside high-quality infant neuroimaging data. In the current study, we aimed to identify infant resting-state functional connectivity associated with both parent report and observed behavioral estimates of infant novelty-evoked distress.
METHODS: Using data from the OIT (Origins of Infant Temperament) study, which includes deep phenotyping of infant temperament, we identified parent-report measures that were associated with observed novelty-evoked distress. These parent-report measures were then summarized into a composite score used for imaging analysis. Our infant magnetic resonance imaging sample was a synthetic cohort, harmonizing data from 2 functional magnetic resonance imaging studies of 4-month-old infants (OIT and BCP [Baby Connectome Project]; n = 101), both of which included measures of parent-reported temperament. Brain-behavior associations were evaluated using enrichment, a statistical approach that quantifies the clustering of brain-behavior associations within network pairs.
RESULTS: Results demonstrated that parent-report composites of novelty-evoked distress were significantly associated with 3 network pairs: dorsal attention-salience/ventral attention, dorsal attention-default mode, and dorsal attention-control. These network pairs demonstrated negative associations with novelty-evoked distress, indicating that less connectivity between these network pairs was associated with greater novelty-evoked distress. Additional analyses demonstrated that dorsal attention-control network connectivity was associated with observed novelty-evoked distress in the OIT sample (n = 38).
CONCLUSIONS: Overall, this work is broadly consistent with existing work and implicates dorsal attention network connectivity in novelty-evoked distress. This study provides novel data on the neural basis of infant novelty-evoked distress.
METHODS: Using data from the OIT (Origins of Infant Temperament) study, which includes deep phenotyping of infant temperament, we identified parent-report measures that were associated with observed novelty-evoked distress. These parent-report measures were then summarized into a composite score used for imaging analysis. Our infant magnetic resonance imaging sample was a synthetic cohort, harmonizing data from 2 functional magnetic resonance imaging studies of 4-month-old infants (OIT and BCP [Baby Connectome Project]; n = 101), both of which included measures of parent-reported temperament. Brain-behavior associations were evaluated using enrichment, a statistical approach that quantifies the clustering of brain-behavior associations within network pairs.
RESULTS: Results demonstrated that parent-report composites of novelty-evoked distress were significantly associated with 3 network pairs: dorsal attention-salience/ventral attention, dorsal attention-default mode, and dorsal attention-control. These network pairs demonstrated negative associations with novelty-evoked distress, indicating that less connectivity between these network pairs was associated with greater novelty-evoked distress. Additional analyses demonstrated that dorsal attention-control network connectivity was associated with observed novelty-evoked distress in the OIT sample (n = 38).
CONCLUSIONS: Overall, this work is broadly consistent with existing work and implicates dorsal attention network connectivity in novelty-evoked distress. This study provides novel data on the neural basis of infant novelty-evoked distress.
摘要：
背景：对婴儿气质的观察性评估为预测社交焦虑的风险提供了无与伦比的见解。然而，将这些评估与高质量的婴儿神经影像学数据一起进行管理和评分具有挑战性.本研究旨在确定与父母报告和观察到的婴儿新奇引起的困扰的行为估计相关的婴儿静息状态功能连接（rsFC）。
方法：使用来自婴儿气质起源（OIT）研究的数据，其中包括婴儿气质的深层表型，我们确定了与观察到的新奇诱发的窘迫相关的家长报告指标.然后将这些家长报告测量结果汇总为用于成像分析的综合评分。我们的婴儿MRI样本是“合成队列”，对来自4个月大婴儿(OIT和BabyConnectomeProject[BCP];n=101)的两项fMRI研究的数据进行协调,这两项研究均包括父母报告的气质。使用“富集，“一种统计方法，可以量化网络对中大脑行为关联的聚类。
结果：结果表明，新颖性诱发的困扰的父母报告复合与三个网络对显著相关：背侧注意力-显著性/腹侧注意力，背部注意-默认,和背部注意力控制。这些网络对表现出与新颖性引起的困扰的负相关，这表明这些网络对之间的连通性较低与新颖性引起的困扰更大相关。其他分析表明，在OIT样本中（n=38），背侧注意力控制网络连接与观察到的新颖性诱发的困扰有关。
结论：总体而言，这项工作与现有工作基本一致，并暗示了新颖性诱发的窘迫中的背侧注意力网络连接。这项研究提供了有关婴儿新奇引起的困扰的神经基础的新数据。
方法：使用来自婴儿气质起源（OIT）研究的数据，其中包括婴儿气质的深层表型，我们确定了与观察到的新奇诱发的窘迫相关的家长报告指标.然后将这些家长报告测量结果汇总为用于成像分析的综合评分。我们的婴儿MRI样本是“合成队列”，对来自4个月大婴儿(OIT和BabyConnectomeProject[BCP];n=101)的两项fMRI研究的数据进行协调,这两项研究均包括父母报告的气质。使用“富集，“一种统计方法，可以量化网络对中大脑行为关联的聚类。
结果：结果表明，新颖性诱发的困扰的父母报告复合与三个网络对显著相关：背侧注意力-显著性/腹侧注意力，背部注意-默认,和背部注意力控制。这些网络对表现出与新颖性引起的困扰的负相关，这表明这些网络对之间的连通性较低与新颖性引起的困扰更大相关。其他分析表明，在OIT样本中（n=38），背侧注意力控制网络连接与观察到的新颖性诱发的困扰有关。
结论：总体而言，这项工作与现有工作基本一致，并暗示了新颖性诱发的窘迫中的背侧注意力网络连接。这项研究提供了有关婴儿新奇引起的困扰的神经基础的新数据。
