Abstract：
The number of different methods of reperfusion therapy to treat venous thromboembolism (VTE) has increased substantially. Nevertheless, investigation of data representativeness and device-level use in administrative databases has been limited. Using the National Inpatient Sample (NIS) and the PINC AI Healthcare Database (PHD), all hospital encounters with a diagnosis code of VTE were identified between January 1, 2016 and December 31, 2020. Patient demographics and trends in treatment modalities were evaluated over time. An algorithm was developed to identify specific devices used for VTE treatment in the PHD cohort. A total of 145,870 patients with VTE treated with reperfusion therapy were identified in the NIS (pulmonary embolism [PE] 88,725, isolated deep vein thrombosis [iDVT] 57,145) and 39,311 in the PHD (PE 25,383, iDVT 13,928). Patient demographics were qualitatively similar in the NIS and PHD. Over time, there was a significant increase in the use of mechanical thrombectomy in the PE and iDVT populations (p <0.05 in both databases), with catheter-directed thrombolysis use plateauing in PE (p = 0.83 and p = 0.14 in NIS and PHD, respectively) and significantly decreasing for the iDVT population (p <0.05 in both databases). In the PHD cohort, specific reperfusion devices were identified in 14,105 patients (PE 9,098, iDVT 5,007). In conclusion, the use of mechanical thrombectomy for the treatment of VTE has increased over time, whereas the rates of catheter-directed thrombolysis therapy have remained stagnant or decreased. Further research is needed to understand the uptake of these treatment modalities and the unique abilities of the PHD to study specific device therapy in the VTE population.
摘要：
治疗静脉血栓栓塞症（VTE）的不同再灌注治疗方法的数量已大大增加。然而，对管理数据库中数据代表性和设备级使用的调查受到限制。使用国家住院患者样本(NIS)和PINCAI医疗保健数据库(PHD)，在2016年1月1日至2020年12月31日期间,所有符合VTE诊断代码的医院均被确认.随着时间的推移，评估了患者的人口统计学和治疗方式的趋势。开发了一种算法来识别PHD队列中用于VTE治疗的特定设备。在NIS（肺栓塞（PE）：88,725;孤立的DVT（iDVT）：57,145）和PHD（PE：25,383;iDVT：13,928）中鉴定了145,870例接受再灌注治疗的VTE患者。NIS和PHD患者的人口统计学在质量上相似。随着时间的推移,在PE和iDVT人群中,机械血栓切除术(MT)的使用显著增加(两个数据库中p<0.05),而在PE中,导管溶栓(CDT)的使用达到平稳(分别在NIS和PHD中p=0.83和p=0.14),在iDVT人群中,机械血栓切除术(MT)的使用显著减少(两个数据库中p<0.05).在博士队列中，在14,105例患者中确定了特定的再灌注装置(PE:9,098;iDVT:5,007).总之,随着时间的推移，MT用于治疗VTE的使用有所增加，而CDT治疗的比率仍然停滞或下降。需要进一步的研究来了解这些治疗方式的吸收以及PHD研究VTE人群中特定设备治疗的独特能力。
