PDF(Pubmed)
Abstract：
Cherubism, an uncommon genetic disorder, manifests as painless swelling in both jaws. A 20-year-old male presented with symmetrical swelling in both the mandible and maxilla. The jaws exhibited bilateral expansion, typical of this condition. Dentofacial abnormalities associated with cherubism stem from mutations in the SH3BP2 gene, which plays a crucial role in regulating osteoblasts and osteoclasts. In summary, cherubism is a genetic disorder characterized by non-cancerous jaw bone lesions. Surgical intervention may be necessary for functional or aesthetic concerns.
摘要：
Cherubism,一种罕见的遗传性疾病,表现为双颌无痛肿胀。一名20岁的男性在下颌骨和上颌骨均表现出对称肿胀。颌骨表现出双侧扩张，这种情况的典型。与天使症相关的牙面异常源于SH3BP2基因的突变，在调节成骨细胞和破骨细胞中起着至关重要的作用。总之,是一种以非癌性颌骨病变为特征的遗传性疾病。手术干预对于功能或美学问题可能是必要的。
