PDF(Pubmed)
Abstract：
Hepatic myelopathy (HM) is a rare neurological complication in the end stage of many liver diseases and is characterized by bilateral spastic paraparesis without sensory and sphincter dysfunction. It occurs owing to metabolic disorders and central nervous system dysfunction associated with cirrhosis. Without timely and effective clinical intervention, the prognosis of these patients is devastating. Although liver transplantation (LT) is an effective treatment for HM, the prognosis of these patients remains unsatisfactory. Early recognition and diagnosis of this disease are essential for improving patient prognosis. Here, we report a case of hepatitis B virus-associated decompensated cirrhosis with HM. The patient recovered well after LT. We also summarize the clinical characteristics and post-transplant outcomes of 25 patients with HM treated by LT through 2023, including this case.
摘要：
肝性脊髓病（HM）是许多肝病晚期的罕见神经系统并发症，其特征是双侧痉挛性轻瘫，无感觉和括约肌功能障碍。它是由于与肝硬化相关的代谢紊乱和中枢神经系统功能障碍而发生的。没有及时有效的临床干预,这些患者的预后是毁灭性的。尽管肝移植（LT）是HM的有效治疗方法，这些患者的预后仍然不能令人满意.这种疾病的早期识别和诊断对于改善患者预后至关重要。这里,我们报告一例乙型肝炎病毒相关性失代偿性肝硬化合并HM。患者在LT后恢复良好。我们还总结了到2023年接受LT治疗的25例HM患者的临床特征和移植后结果，包括本例。
