PDF(Pubmed)
Abstract：
UNASSIGNED: Disease progression of chronic hepatitis B virus (HBV) infection is driven by the interactions between viral replication and the host immune response against the infection. This study aimed to clarify the relationship between HBV replication and hepatic inflammation during disease progression.
UNASSIGNED: Two cross-sectional, one validation cohort, and meta-analyses were used to explore the relationship between HBV replication and liver inflammation. Spearman analysis, multiple linear regression, and logistic regression were used to explore the relationship between variables.
UNASSIGNED: In the cross-sectional cohorts A and B including 1,350 chronic hepatitis B patients, Spearman analysis revealed a negative relationship between HBV replication (such as HBV DNA) and liver inflammation (such as ALT) in HBeAg-positive patients with higher HBV DNA >2×106 IU/mL (rho=-0.160 and -0.042) which turned to be positive in HBeAg-positive patients with HBV DNA ≤2×106 IU/mL (rho=0.278 and 0.260) and HBeAg-negative patients (rho=0.450 and 0.363). After adjustment for sex, age, and anti-HBe, results from logistic regression and multiple linear regression showed the opposite relationship still existed in HBeAg-positive patients with different DNA levels; the opposite relationship in HBeAg-positive patients with different DNA levels was validated in a third cohort; the opposite relationship in patients with different HBeAg status was partially confirmed by meta-analysis (overall R: -0.004 vs 0.481).
UNASSIGNED: These results suggested a negative relationship between viral replication and liver inflammation in HBeAg-positive patients with high HBV DNA, which changed to a positive relationship for those HBeAg-positive patients with DNA less than 2×106 IU/mL and HBeAg-negative patients.
UNASSIGNED: Two cross-sectional, one validation cohort, and meta-analyses were used to explore the relationship between HBV replication and liver inflammation. Spearman analysis, multiple linear regression, and logistic regression were used to explore the relationship between variables.
UNASSIGNED: In the cross-sectional cohorts A and B including 1,350 chronic hepatitis B patients, Spearman analysis revealed a negative relationship between HBV replication (such as HBV DNA) and liver inflammation (such as ALT) in HBeAg-positive patients with higher HBV DNA >2×106 IU/mL (rho=-0.160 and -0.042) which turned to be positive in HBeAg-positive patients with HBV DNA ≤2×106 IU/mL (rho=0.278 and 0.260) and HBeAg-negative patients (rho=0.450 and 0.363). After adjustment for sex, age, and anti-HBe, results from logistic regression and multiple linear regression showed the opposite relationship still existed in HBeAg-positive patients with different DNA levels; the opposite relationship in HBeAg-positive patients with different DNA levels was validated in a third cohort; the opposite relationship in patients with different HBeAg status was partially confirmed by meta-analysis (overall R: -0.004 vs 0.481).
UNASSIGNED: These results suggested a negative relationship between viral replication and liver inflammation in HBeAg-positive patients with high HBV DNA, which changed to a positive relationship for those HBeAg-positive patients with DNA less than 2×106 IU/mL and HBeAg-negative patients.
摘要：
■慢性乙型肝炎病毒（HBV）感染的疾病进展是由病毒复制和宿主对感染的免疫反应之间的相互作用驱动的。本研究旨在阐明疾病进展过程中HBV复制与肝脏炎症之间的关系。
■两个横截面，一个验证队列，和荟萃分析用于探讨HBV复制与肝脏炎症之间的关系。斯皮尔曼分析,多元线性回归，和logistic回归分析变量之间的关系。
■在包括1,350例慢性乙型肝炎患者的横断面A和B组中，Spearman分析显示，HBVDNA>2×106IU/mL（rho=-0.160和-0.042）的HBeAg阳性患者的HBV复制（如HBVDNA）和肝脏炎症（如ALT）之间存在负相关。在性别调整后，年龄,和反HBe，从逻辑回归和多元线性回归结果显示，在不同DNA水平的HBeAg阳性患者中仍然存在相反的关系;在不同DNA水平的HBeAg阳性患者中相反的关系在第三个队列中得到验证;不同HBeAg状态患者的相反关系部分通过荟萃分析得到证实（总体R：-0.004vs0.481）。
■这些结果表明病毒复制和肝脏炎症之间的负相关在HBeAg阳性患者与高HBVDNA，对于那些DNA小于2×106IU/mL的HBeAg阳性患者和HBeAg阴性患者，其变化为正相关。
■两个横截面，一个验证队列，和荟萃分析用于探讨HBV复制与肝脏炎症之间的关系。斯皮尔曼分析,多元线性回归，和logistic回归分析变量之间的关系。
■在包括1,350例慢性乙型肝炎患者的横断面A和B组中，Spearman分析显示，HBVDNA>2×106IU/mL（rho=-0.160和-0.042）的HBeAg阳性患者的HBV复制（如HBVDNA）和肝脏炎症（如ALT）之间存在负相关。在性别调整后，年龄,和反HBe，从逻辑回归和多元线性回归结果显示，在不同DNA水平的HBeAg阳性患者中仍然存在相反的关系;在不同DNA水平的HBeAg阳性患者中相反的关系在第三个队列中得到验证;不同HBeAg状态患者的相反关系部分通过荟萃分析得到证实（总体R：-0.004vs0.481）。
■这些结果表明病毒复制和肝脏炎症之间的负相关在HBeAg阳性患者与高HBVDNA，对于那些DNA小于2×106IU/mL的HBeAg阳性患者和HBeAg阴性患者，其变化为正相关。
