Abstract：
Polycystic Ovary Syndrome (PCOS) is a multifaceted condition influenced by genetic, hormonal, and environmental factors. Among environmental factors, Bisphenol A (BPA)-a recognized endocrine disruptor-has been implicated in the development of PCOS. The study aimed to compare BPA levels in women diagnosed with PCOS with those in healthy controls, using the high-performance liquid chromatography (HPLC) technique. The study involved 80 women diagnosed with PCOS and 50 healthy control participants. Demographic and biochemical parameters were recorded, including age, Body Mass Index (BMI), and levels of testosterone, estradiol, Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Prolactin (PRL), Dehydroepiandrosterone Sulfate (DHEA-S), Thyroid Stimulating Hormone (TSH), and Insulin Resistance as measured by the Homeostatic Model Assessment (HOMA-IR). Furthermore, BPA levels were measured using the HPLC technique. Women with PCOS exhibited significantly higher mean age and BMI compared to healthy controls (p = 0.01, p < 0.0001, respectively). Additionally, higher levels of testosterone (p = 0.04), LH (p = 0.03) and BPA (p < 0.0001) were observed in women with PCOS. However, estradiol, FSH, PRL, LH/FSH ratio, DHEA-S, and TSH levels were not significantly different between the two groups. HOMA-IR levels were not recorded for the control group. A notable positive relationship emerged between Bisphenol A and luteinizing hormone (LH) levels (r = 0.23, p = 0.03), also significant negative correlation appeared between Bisphenol A and thyroid-stimulating hormone (TSH) levels. This study found that women with PCOS have elevated BPA levels compared with healthy controls, showing a need for further research on the relationship between BPA exposure and the development of PCOS.
摘要：
多囊卵巢综合征（PCOS）是一种受遗传影响的多方面疾病，荷尔蒙，和环境因素。在环境因素中，双酚A（BPA）-一种公认的内分泌干扰物-与PCOS的发展有关。该研究旨在比较诊断为PCOS的女性与健康对照组的BPA水平，使用高效液相色谱（HPLC）技术。该研究涉及80名诊断为PCOS的女性和50名健康对照参与者。记录人口统计学和生化参数，包括年龄,身体质量指数(BMI),和睾丸激素水平，雌二醇,促黄体激素(LH),卵泡刺激素(FSH),催乳素（PRL），硫酸脱氢表雄酮（DHEA-S），促甲状腺激素(TSH),和通过稳态模型评估(HOMA-IR)测量的胰岛素抵抗。此外，使用HPLC技术测量BPA水平。与健康对照组相比，患有PCOS的女性表现出明显更高的平均年龄和BMI（分别为p=0.01，p<0.0001）。此外,睾酮水平较高（p=0.04），在PCOS女性中观察到LH（p=0.03）和BPA（p<0.0001）。然而,雌二醇,FSH,PRL,LH/FSH比值,DHEA-S,和TSH水平在两组之间没有显着差异。对照组未记录HOMA-IR水平。双酚A和黄体生成素（LH）水平之间出现显著的正相关（r=0.23，p=0.03），双酚A与促甲状腺激素(TSH)水平呈显著负相关。这项研究发现，与健康对照组相比，患有PCOS的女性BPA水平升高，表明需要进一步研究BPA暴露与PCOS发展之间的关系。
