Abstract：
BACKGROUND: Eczema and contact dermatitis are relatively common, non-life-threatening disease, but can reduce the patient\'s quality-of-life when it becomes chronic. This study describes two cases of bee venom acupuncture (BVA) and herbal medicine (San Wu Huangqin decoction; SWH) co-treatment for hand eczema and contact dermatitis, then confirms the effect of the combination therapy in an in vivo model of eczema.
METHODS: A 56-year-old female (case 1) and a 33-year-old male (case 2) presented to the clinic with symptoms of itching and erythema (case 1), and scaliness (case 2) on both hands. Both were diagnosed with hand eczema and contact dermatitis based on examination of the erythema and scaliness. They were treated with BVA and SWH for three months. The lesions were healed and had not recurred after 1 and 3 years of follow-up. A mouse study was conducted by repeated application of 2,4-dinitrochlorobenzene (DNCB) to induce eczema-like contact dermatitis in Balb/c mice. In a DNCB-induced eczema-like contact dermatitis model, BVA and SWH co-administration synergistically improved clinical symptoms seen in eczema. Also, they improved histological changes of the skin, suppressed immune cell infiltration, and decreased inflammatory cytokines and immunoglobulin E in the serum.
CONCLUSIONS: This study suggests BVA and SWH could be an alternative treatment for eczema and contact dermatitis.
METHODS: A 56-year-old female (case 1) and a 33-year-old male (case 2) presented to the clinic with symptoms of itching and erythema (case 1), and scaliness (case 2) on both hands. Both were diagnosed with hand eczema and contact dermatitis based on examination of the erythema and scaliness. They were treated with BVA and SWH for three months. The lesions were healed and had not recurred after 1 and 3 years of follow-up. A mouse study was conducted by repeated application of 2,4-dinitrochlorobenzene (DNCB) to induce eczema-like contact dermatitis in Balb/c mice. In a DNCB-induced eczema-like contact dermatitis model, BVA and SWH co-administration synergistically improved clinical symptoms seen in eczema. Also, they improved histological changes of the skin, suppressed immune cell infiltration, and decreased inflammatory cytokines and immunoglobulin E in the serum.
CONCLUSIONS: This study suggests BVA and SWH could be an alternative treatment for eczema and contact dermatitis.
摘要：
背景：湿疹和接触性皮炎相对常见，不危及生命的疾病,但是当患者变得慢性时，会降低患者的生活质量。本研究描述了蜂毒针刺（BVA）和中药（三五黄芩汤；SWH）共同治疗手部湿疹和接触性皮炎的2例，然后证实联合治疗在湿疹体内模型中的效果。
方法：一名56岁女性（病例1）和一名33岁男性（病例2）出现瘙痒和红斑症状（病例1），和鳞屑（案例2）在双手。根据红斑和鳞屑的检查，均诊断为手部湿疹和接触性皮炎。他们用BVA和SWH治疗三个月。随访1年和3年，病灶均愈合，未复发。通过重复应用2,4-二硝基氯苯(DNCB)在Balb/c小鼠中诱导湿疹样接触性皮炎进行小鼠研究。在DNCB诱导的湿疹样接触性皮炎模型中，BVA和SWH共同给药协同改善了湿疹中的临床症状。此外，他们改善了皮肤的组织学变化，抑制免疫细胞浸润，并降低血清中的炎性细胞因子和免疫球蛋白E。
结论：本研究提示BVA和SWH可作为湿疹和接触性皮炎的替代治疗方法。
方法：一名56岁女性（病例1）和一名33岁男性（病例2）出现瘙痒和红斑症状（病例1），和鳞屑（案例2）在双手。根据红斑和鳞屑的检查，均诊断为手部湿疹和接触性皮炎。他们用BVA和SWH治疗三个月。随访1年和3年，病灶均愈合，未复发。通过重复应用2,4-二硝基氯苯(DNCB)在Balb/c小鼠中诱导湿疹样接触性皮炎进行小鼠研究。在DNCB诱导的湿疹样接触性皮炎模型中，BVA和SWH共同给药协同改善了湿疹中的临床症状。此外，他们改善了皮肤的组织学变化，抑制免疫细胞浸润，并降低血清中的炎性细胞因子和免疫球蛋白E。
结论：本研究提示BVA和SWH可作为湿疹和接触性皮炎的替代治疗方法。
