Abstract：
Oxygen supplementation is a widely used treatment for ICU patients. However, it can lead to hyperoxia, which in turn can result in oxidative stress, cardiac remodeling, and even mortality. This paper expands upon previous research conducted by our lab to establish time-dependent cardiac changes under hyperoxia. In this study, both young and aged mice (male and female) underwent 72 h of hyperoxia exposure and were monitored at 24-hour intervals for cardiac electrophysiological and functional parameters using ECG and electrocardiogram data. Our analysis showed that young male mice experienced significant weight loss as well as significant lung edema by 48 h. Although young male mice were highly susceptible to physical changes, they were resistant to early cardiac functional and electrophysiological changes compared to the other groups. Both young and aged female and aged males developed functional impairments by 24 h of hyperoxia exposure. Furthermore, sex and age differences were noted in the onset of electrophysiological changes. While some groups could resist early cardiac remodeling, our data suggests that 72 h of hyperoxia exposure is sufficient to induce significant cardiac remodeling across all age and sex groups. Our data establishes that time-dependent cardiac changes due to oxygen supplementation can have devastating consequences even with short exposure periods. These findings can aid in developing clinical practices for individuals admitted to the ICU by elucidating the impact of aging, sex, and length of stay under mechanical ventilation to limit hyperoxia-induced cardiac remodeling.
摘要：
氧气补充是ICU患者广泛使用的治疗方法。然而,会导致高氧,这反过来会导致氧化应激，心脏重塑,甚至死亡率。本文扩展了我们实验室先前进行的研究，以建立高氧下的时间依赖性心脏变化。在这项研究中,年轻和老年小鼠(雄性和雌性)均经历了72小时的高氧暴露,并使用ECG和心电图数据每隔24小时监测心脏电生理和功能参数.我们的分析表明，年轻的雄性小鼠在48小时内经历了显着的体重减轻和显着的肺水肿。尽管年轻的雄性小鼠对身体变化高度敏感，与其他组相比，他们对早期心脏功能和电生理变化具有抵抗力。在高氧暴露24小时后，年轻和老年女性和老年男性都出现了功能障碍。此外，在电生理变化的发作中注意到性别和年龄差异。虽然一些群体可以抵抗早期心脏重塑，我们的数据表明,在所有年龄和性别人群中,72小时的高氧暴露足以诱导显著的心脏重构.我们的数据表明，即使在短时间的暴露时间内，由于补充氧气而引起的时间依赖性心脏变化也可能产生破坏性后果。这些发现可以通过阐明衰老的影响来帮助进入ICU的个人制定临床实践，性别,和在机械通气下的停留时间，以限制高氧诱导的心脏重塑。
