PDF(Pubmed)
Abstract：
Pregabalin is the first-line treatment for neuropathic pain. Cases of cutaneous hypersensitivity reactions caused by pregabalin generally occur within 2 weeks of initiating medication. We report a rare case of a delayed cutaneous hypersensitivity reaction caused by pregabalin, which was confirmed by a drug provocation test. A 72-year-old man with severe herpes zoster neuralgia developed maculopapular drug eruption covering 80% to 90% of his total body surface area after 40 days of combined multidrug analgesia. A drug provocation test for pregabalin was positive. The time interval between initiating medication and the onset of the patient\'s rash was the longest and he also had the largest area of skin affected compared with patients with a similar condition in previous related reports. Remaining vigilant for possible adverse cutaneous hypersensitivity reactions during treatment is important because of the long-term course of pregabalin treatment for neuropathic pain.
摘要：
普瑞巴林是治疗神经性疼痛的一线药物。由普瑞巴林引起的皮肤超敏反应的病例通常发生在开始用药的2周内。我们报告了一例罕见的由普瑞巴林引起的迟发型皮肤超敏反应，药物激发试验证实了这一点。一名72岁的患有严重带状疱疹神经痛的男子在接受多药联合镇痛40天后，出现了占其全身表面积80％至90％的斑丘疹药疹。普瑞巴林的药物激发试验为阳性。与以前的相关报告中类似情况的患者相比，开始用药与患者皮疹发作之间的时间间隔最长，并且他的皮肤受影响面积最大。由于普瑞巴林治疗神经性疼痛的长期过程，因此在治疗期间对可能的不良皮肤超敏反应保持警惕很重要。
