Abstract：
OBJECTIVE: Rapidly aging societies have become a major issue worldwide including Japan. This study aimed to elucidate relative changes in the characteristics of inpatients in Japan related to this issue.
METHODS: A total of 23 835 Japanese inpatients treated from 2010 to 2021 were enrolled (2010-2013, period I; 2014-2017, period II; 2018-2021, period III). Changes in clinical features were retrospectively analyzed based on ICD-10 diagnosis data.
RESULTS: The percentage of patients aged over 75 years increased over time (period I, 38.0%; II, 39.5%, III, 41.4%). Emergency admissions comprised 27.5% of all in period I, which increased to 43.2% in period II and again to 44.5% in period III (P < 0.001). In period I, gastrointestinal disease, liver disease, pancreatic-biliary disease, and other disease types were noted in 47.4%, 29.5%, 19.2%, and 3.9%, respectively, while those values were 44.0%, 18.0%, 33.9%, and 4.1%, respectively, in period III (P < 0.001). The frequency of liver disease decreased by approximately 0.6-fold from periods I to III, while that of biliary-pancreatic disease increased by approximately 1.8-fold during that time. Both percentage and actual numbers of patients with biliary-pancreatic disease increased during the examined periods. Analysis of changes in the proportion of organs affected by malignancy during periods I, II, and III showed a marked increase in cases of biliary-pancreatic malignancy (11.6%, 19.5%, 26.6%, respectively) (P < 0.001).
CONCLUSIONS: In association with the rapidly aging Japanese society, there has been an increasing frequency of biliary-pancreatic disease cases requiring hospitalization for treatment in the west Japan region of Shikoku.
METHODS: A total of 23 835 Japanese inpatients treated from 2010 to 2021 were enrolled (2010-2013, period I; 2014-2017, period II; 2018-2021, period III). Changes in clinical features were retrospectively analyzed based on ICD-10 diagnosis data.
RESULTS: The percentage of patients aged over 75 years increased over time (period I, 38.0%; II, 39.5%, III, 41.4%). Emergency admissions comprised 27.5% of all in period I, which increased to 43.2% in period II and again to 44.5% in period III (P < 0.001). In period I, gastrointestinal disease, liver disease, pancreatic-biliary disease, and other disease types were noted in 47.4%, 29.5%, 19.2%, and 3.9%, respectively, while those values were 44.0%, 18.0%, 33.9%, and 4.1%, respectively, in period III (P < 0.001). The frequency of liver disease decreased by approximately 0.6-fold from periods I to III, while that of biliary-pancreatic disease increased by approximately 1.8-fold during that time. Both percentage and actual numbers of patients with biliary-pancreatic disease increased during the examined periods. Analysis of changes in the proportion of organs affected by malignancy during periods I, II, and III showed a marked increase in cases of biliary-pancreatic malignancy (11.6%, 19.5%, 26.6%, respectively) (P < 0.001).
CONCLUSIONS: In association with the rapidly aging Japanese society, there has been an increasing frequency of biliary-pancreatic disease cases requiring hospitalization for treatment in the west Japan region of Shikoku.
摘要：
目标：快速老龄化社会已成为包括日本在内的全球主要问题。本研究旨在阐明与此问题相关的日本住院患者特征的相对变化。
方法：共纳入2010年至2021年接受治疗的23835例日本住院患者（2010-2013年，I期；2014-2017年，II期；2018-2021年，III期）。根据ICD-10诊断数据回顾性分析临床特征的变化。
结果：75岁以上患者的百分比随着时间的推移而增加（I期，38.0%;二、39.5%,III,41.4%）。急诊入院占第一阶段总入院人数的27.5%，在第二阶段增加到43.2%，在第三阶段再次增加到44.5%(P<0.001)。在第一阶段,胃肠道疾病,肝病,胰胆疾病,其他疾病类型占47.4%，29.5%,19.2%,和3.9%，分别,而这些值是44.0%，18.0%,33.9%,和4.1%，分别,在III期（P<0.001）。从I到III期，肝病的频率降低了约0.6倍，而胆胰疾病在此期间增加了约1.8倍。在检查期间，胆胰疾病患者的百分比和实际人数均增加。分析I期间受恶性肿瘤影响的器官比例变化，II,和III显示胆胰恶性肿瘤的病例明显增加（11.6％，19.5%,26.6%,分别)(P<0.001)。
结论：与迅速老龄化的日本社会有关，在日本西部四国地区,需要住院治疗的胆胰疾病病例越来越频繁.
方法：共纳入2010年至2021年接受治疗的23835例日本住院患者（2010-2013年，I期；2014-2017年，II期；2018-2021年，III期）。根据ICD-10诊断数据回顾性分析临床特征的变化。
结果：75岁以上患者的百分比随着时间的推移而增加（I期，38.0%;二、39.5%,III,41.4%）。急诊入院占第一阶段总入院人数的27.5%，在第二阶段增加到43.2%，在第三阶段再次增加到44.5%(P<0.001)。在第一阶段,胃肠道疾病,肝病,胰胆疾病,其他疾病类型占47.4%，29.5%,19.2%,和3.9%，分别,而这些值是44.0%，18.0%,33.9%,和4.1%，分别,在III期（P<0.001）。从I到III期，肝病的频率降低了约0.6倍，而胆胰疾病在此期间增加了约1.8倍。在检查期间，胆胰疾病患者的百分比和实际人数均增加。分析I期间受恶性肿瘤影响的器官比例变化，II,和III显示胆胰恶性肿瘤的病例明显增加（11.6％，19.5%,26.6%,分别)(P<0.001)。
结论：与迅速老龄化的日本社会有关，在日本西部四国地区,需要住院治疗的胆胰疾病病例越来越频繁.
