Abstract：
DNA origami is a flexible platform for the precise organization of nano-objects, enabling numerous applications from biomedicine to nano-photonics. Its huge potential stems from its high flexibility that allows customized structures to meet specific requirements. The ability to generate diverse final structures from a common base by folding significantly enhances design variety and is regularly occurring in liquid. This study describes a novel approach that combines top-down lithography with bottom-up DNA origami techniques to control folding of the DNA origami with the adsorption on pre-patterned surfaces. Using this approach, tunable plasmonic dimer nano-arrays are fabricated on a silicon surface. This involves employing electron beam lithography to create adsorption sites on the surface and utilizing self-organized adsorption of DNA origami functionalized with two gold nanoparticles (AuNPs). The desired folding of the DNA origami helices can be controlled by the size and shape of the adsorption sites. This approach can for example be used to tune the center-to-center distance of the AuNPs dimers on the origami template. To demonstrate this technique\'s efficiency, the Raman signal of dye molecules (carboxy tetramethylrhodamine, TAMRA) coated on the AuNPs surface are investigated. These findings highlight the potential of tunable DNA origami-based plasmonic nanostructures for many applications.
摘要：
DNA折纸是一个灵活的平台，用于精确组织纳米物体，实现从生物医学到纳米光子学的众多应用。其巨大的潜力源于其高度的灵活性，允许定制的结构，以满足特定的要求。通过折叠从共同的基底产生不同的最终结构的能力显著增强了设计多样性,并且经常发生在液体中。这项研究描述了一种新颖的方法，该方法将自上而下的光刻技术与自下而上的DNA折纸技术相结合，以控制DNA折纸的折叠以及在预图案化表面上的吸附。使用这种方法，在硅表面上制造可调谐等离子体二聚体纳米阵列。这涉及使用电子束光刻在表面上创建吸附位点，并利用用两个金纳米颗粒（AuNP）功能化的DNA折纸的自组织吸附。DNA折纸螺旋的期望折叠可以通过吸附位点的大小和形状来控制。该方法可以例如用于调整折纸模板上的AuNP二聚体的中心到中心距离。为了证明这种技术的效率，染料分子的拉曼信号(羧基四甲基罗丹明，研究了涂在AuNP表面上的TAMRA）。这些发现突出了可调DNA折纸基等离子体纳米结构在许多应用中的潜力。
