PDF(Pubmed)
Abstract：
BACKGROUND: Stromal vascular fraction (SVF) cells derived from adipose tissue and platelet-rich plasma (PRP) are among novel treatments for androgenetic alopecia (AGA). We aimed to investigate the effect of adding SVF to PRP and compare it to administering PRP injection alone.
METHODS: Eighteen patients were randomly divided into two groups of nine. The PRP group was treated with PRP at all three visits at 1-month intervals, while the SVF-PRP group received an SVF injection on the first visit and a PRP injection on the second and third visits. Each group was evaluated at baseline and 20 weeks after the therapy\'s initiation.
RESULTS: Changes in mean hair diameter and hair count compared to baseline were significant in both groups. The PRP group experienced a greater increase in mean hair count than the SVF-PRP group, and the SVF-PRP group had a marginally greater increase in hair diameter than the PRP group. These differences were not statistically significant compared to each other. The patient and physician assessment scores exceeded the mean (on a scale from 0: poor to 3: excellent) in both groups.
CONCLUSIONS: Adding one SVF injection to two PRP treatment sessions versus three PRP injections alone had no significant difference in evaluated variables. If additional research demonstrates the same results, we suggest that multiple SVF injection sessions may be required to produce a statistically significant difference compared to PRP injection alone. Moreover, considering lower cost and greater accessibility of PRP, it can be used before SVF in the treatment of AGA.
METHODS: Eighteen patients were randomly divided into two groups of nine. The PRP group was treated with PRP at all three visits at 1-month intervals, while the SVF-PRP group received an SVF injection on the first visit and a PRP injection on the second and third visits. Each group was evaluated at baseline and 20 weeks after the therapy\'s initiation.
RESULTS: Changes in mean hair diameter and hair count compared to baseline were significant in both groups. The PRP group experienced a greater increase in mean hair count than the SVF-PRP group, and the SVF-PRP group had a marginally greater increase in hair diameter than the PRP group. These differences were not statistically significant compared to each other. The patient and physician assessment scores exceeded the mean (on a scale from 0: poor to 3: excellent) in both groups.
CONCLUSIONS: Adding one SVF injection to two PRP treatment sessions versus three PRP injections alone had no significant difference in evaluated variables. If additional research demonstrates the same results, we suggest that multiple SVF injection sessions may be required to produce a statistically significant difference compared to PRP injection alone. Moreover, considering lower cost and greater accessibility of PRP, it can be used before SVF in the treatment of AGA.
摘要：
背景：来自脂肪组织和富含血小板的血浆（PRP）的基质血管部分（SVF）细胞是雄激素性脱发（AGA）的新型治疗方法之一。我们旨在研究向PRP中添加SVF的效果，并将其与单独施用PRP注射液进行比较。
方法：18例患者随机分为两组，每组9例。PRP组在所有3次访问中均以1个月的间隔接受PRP治疗，而SVF-PRP组在第一次访视时注射SVF,第二次和第三次访视时注射PRP.每组在基线和治疗开始后20周进行评估。
结果：与基线相比，两组平均毛发直径和毛发计数的变化均显着。与SVF-PRP组相比，PRP组的平均毛发数量增加更大，SVF-PRP组比PRP组有稍大的毛发直径增加。这些差异彼此之间相比没有统计学意义。两组患者和医生的评估得分均超过平均值（从0：差到3：优）。
结论：在两次PRP治疗中添加一次SVF注射与单独三次PRP注射在评估变量上没有显著差异。如果额外的研究证明了同样的结果，我们建议,与单独注射PRP相比,可能需要多次注射SVF才能产生统计学显著差异.此外，考虑到PRP的更低的成本和更大的可及性，它可以在治疗AGA之前使用SVF。
方法：18例患者随机分为两组，每组9例。PRP组在所有3次访问中均以1个月的间隔接受PRP治疗，而SVF-PRP组在第一次访视时注射SVF,第二次和第三次访视时注射PRP.每组在基线和治疗开始后20周进行评估。
结果：与基线相比，两组平均毛发直径和毛发计数的变化均显着。与SVF-PRP组相比，PRP组的平均毛发数量增加更大，SVF-PRP组比PRP组有稍大的毛发直径增加。这些差异彼此之间相比没有统计学意义。两组患者和医生的评估得分均超过平均值（从0：差到3：优）。
结论：在两次PRP治疗中添加一次SVF注射与单独三次PRP注射在评估变量上没有显著差异。如果额外的研究证明了同样的结果，我们建议,与单独注射PRP相比,可能需要多次注射SVF才能产生统计学显著差异.此外，考虑到PRP的更低的成本和更大的可及性，它可以在治疗AGA之前使用SVF。
