PDF(Pubmed)
Abstract：
UNASSIGNED: Kenya has implemented a national school-based deworming program, which has led to substantial decline in the prevalence of soil-transmitted helminths (STHs), although some pockets of infections remain. To effectively design an STH control program that leads to significant reductions of Trichuris trichiura, there is a need to understand the drivers of persistent infection despite ongoing treatment programs.
UNASSIGNED: This study was conducted between July and September 2019 at the south coast of Kenya, using a two-stage sampling design. First, a school-based cross-sectional survey was conducted in 2265 randomly selected school children from selected schools in areas known to be endemic for T. trichiura. After this, we conducted a nested case-control study wherein all children positive for T. trichiura (142) were matched to 148 negative controls based on age and village. A household survey was then conducted with all household members of cases and controls. In addition, a subsample of 116 children found to be infected with T. trichiura were followed up to assess the efficacy of albendazole at day 21 post-treatment. The predictors of presence of T. trichiura were investigated through multilevel logistic regression, considering clustering of infection.
UNASSIGNED: Overall, 34.4% of the children were infected with at least one STH species; T. trichiura was the most common (28.3%), 89.1% of those with T. trichiura had light-intensity infections. The prevalence of T. trichiura was significantly higher in male children and was positively associated with younger age and number of people infected with T. trichiura in a household. The parasitological cure rate and egg reduction rate of T. trichiura were 35% and 51%, respectively. Other STHs identified were hookworm (9.6%) and Ascaris lumbricoides (5.7%).
UNASSIGNED: T. trichiura remains a significant public health challenge in the study area with albendazole treatment efficacy against the parasite, remaining lower than the World Health Organization-recommended thresholds. Because of the observed focal transmission of T. trichiura in the current area, control efforts tailored to local conditions and targeting lower implementation units should be used to achieve optimal results on transmission.
UNASSIGNED: This study was conducted between July and September 2019 at the south coast of Kenya, using a two-stage sampling design. First, a school-based cross-sectional survey was conducted in 2265 randomly selected school children from selected schools in areas known to be endemic for T. trichiura. After this, we conducted a nested case-control study wherein all children positive for T. trichiura (142) were matched to 148 negative controls based on age and village. A household survey was then conducted with all household members of cases and controls. In addition, a subsample of 116 children found to be infected with T. trichiura were followed up to assess the efficacy of albendazole at day 21 post-treatment. The predictors of presence of T. trichiura were investigated through multilevel logistic regression, considering clustering of infection.
UNASSIGNED: Overall, 34.4% of the children were infected with at least one STH species; T. trichiura was the most common (28.3%), 89.1% of those with T. trichiura had light-intensity infections. The prevalence of T. trichiura was significantly higher in male children and was positively associated with younger age and number of people infected with T. trichiura in a household. The parasitological cure rate and egg reduction rate of T. trichiura were 35% and 51%, respectively. Other STHs identified were hookworm (9.6%) and Ascaris lumbricoides (5.7%).
UNASSIGNED: T. trichiura remains a significant public health challenge in the study area with albendazole treatment efficacy against the parasite, remaining lower than the World Health Organization-recommended thresholds. Because of the observed focal transmission of T. trichiura in the current area, control efforts tailored to local conditions and targeting lower implementation units should be used to achieve optimal results on transmission.
摘要：
■肯尼亚实施了一项全国学校驱虫计划，这导致土壤传播的蠕虫（STHs）的患病率大幅下降，尽管仍然存在一些感染。为了有效地设计导致Trichuristrichiura显着减少的STH控制程序，尽管正在进行治疗计划,但仍需要了解持续感染的驱动因素.
■这项研究于2019年7月至9月在肯尼亚南海岸进行，采用两阶段抽样设计。首先,在已知Trichiura流行地区的部分学校中随机选择的2265名学童中进行了一项基于学校的横断面调查。在这之后,我们进行了一项巢式病例对照研究,其中所有TrichiuraT.(142)阳性儿童与148名阴性对照根据年龄和村庄进行匹配.然后对病例和对照的所有家庭成员进行了家庭调查。此外,在治疗后第21天,我们对116名被发现感染TrichiuraT.的儿童进行了随访,以评估阿苯达唑的疗效.通过多水平逻辑回归研究了T.trichiura存在的预测因素，考虑到感染的聚类。
■总的来说，34.4%的儿童感染了至少一种STH；T.trichiura是最常见的(28.3%)，89.1%的Trichiura患者有光照强度感染。在男性儿童中，T.trichiura的患病率显着升高，并且与较年轻的年龄和家庭中感染T.trichiura的人数呈正相关。毛虫的寄生虫治愈率和减卵率分别为35%和51%，分别。确定的其他STH是钩虫（9.6％）和A虫（5.7％）。
■T.在阿苯达唑对寄生虫的治疗效果研究领域，trichilura仍然是一个重大的公共卫生挑战，低于世界卫生组织建议的阈值。由于在当前区域观察到T.trichiura的局灶性传播，应根据当地条件和针对较低执行单位的控制努力，以实现传输的最佳结果。
■这项研究于2019年7月至9月在肯尼亚南海岸进行，采用两阶段抽样设计。首先,在已知Trichiura流行地区的部分学校中随机选择的2265名学童中进行了一项基于学校的横断面调查。在这之后,我们进行了一项巢式病例对照研究,其中所有TrichiuraT.(142)阳性儿童与148名阴性对照根据年龄和村庄进行匹配.然后对病例和对照的所有家庭成员进行了家庭调查。此外,在治疗后第21天,我们对116名被发现感染TrichiuraT.的儿童进行了随访,以评估阿苯达唑的疗效.通过多水平逻辑回归研究了T.trichiura存在的预测因素，考虑到感染的聚类。
■总的来说，34.4%的儿童感染了至少一种STH；T.trichiura是最常见的(28.3%)，89.1%的Trichiura患者有光照强度感染。在男性儿童中，T.trichiura的患病率显着升高，并且与较年轻的年龄和家庭中感染T.trichiura的人数呈正相关。毛虫的寄生虫治愈率和减卵率分别为35%和51%，分别。确定的其他STH是钩虫（9.6％）和A虫（5.7％）。
■T.在阿苯达唑对寄生虫的治疗效果研究领域，trichilura仍然是一个重大的公共卫生挑战，低于世界卫生组织建议的阈值。由于在当前区域观察到T.trichiura的局灶性传播，应根据当地条件和针对较低执行单位的控制努力，以实现传输的最佳结果。
