PDF(Pubmed)
Abstract：
Driving pressure (∆P) is a core therapeutic component of mechanical ventilation (MV). Varying levels of ∆P have been employed during MV depending on the type of underlying pathology and severity of injury. However, ∆P levels have also been shown to closely impact hard endpoints such as mortality. Considering this, conducting an in-depth review of ∆P as a unique, outcome-impacting therapeutic modality is extremely important. There is a need to understand the subtleties involved in making sure ∆P levels are optimized to enhance outcomes and minimize harm. We performed this narrative review to further explore the various uses of ∆P, the different parameters that can affect its use, and how outcomes vary in different patient populations at different pressure levels. To better utilize ∆P in MV-requiring patients, additional large-scale clinical studies are needed.
摘要：
驱动压力（ΔP）是机械通气（MV）的核心治疗成分。在MV期间，根据潜在病理类型和损伤的严重程度，使用了不同水平的ΔP。然而,ΔP水平也被证明对死亡率等硬终点有密切的影响。考虑到这一点,进行了深入的审查作为一个独特的ΔP，影响预后的治疗方式极为重要.有必要了解确保ΔP水平得到优化以增强结果并最大程度地减少伤害所涉及的微妙之处。我们进行了这篇叙述性综述，以进一步探讨ΔP的各种用途，可能影响其使用的不同参数，以及不同患者人群在不同压力水平下的结果如何变化。为了在需要MV的患者中更好地利用ΔP，还需要更多的大规模临床研究.
