Abstract：
OBJECTIVE: To determine the relationship between changes in accommodative and binocular function with myopia progression in myopic children over a two-year follow-up period, and to determine when changes in visual functions stabilized after switching from spectacles to orthokeratology (Ortho-K).
METHODS: This prospective, self-controlled study followed thirty-six participants (aged 8-14 years) for two years after they switched from spectacles to Ortho-K. Accommodative and binocular function were assessed prior to and 1, 3, 6, 12, 18 and 24 months after commencing Ortho-K. Measurements included accommodative amplitude, accommodative response, accommodative facility, accommodative convergence/accommodation (AC/A), ocular alignment, positive relative accommodation (PRA), negative relative accommodation (NRA), horizontal vergence range, reading ability and stereoacuity. Myopia progression was quantified by the change in axial length.
RESULTS: Ocular alignment, monocular and binocular accommodative facility, and PRA stabilized after 1 month. The distance blur point in the convergence range, the distance break and recovery point in the divergence range, accommodative amplitude, calculated AC/A, stereoacuity and reading ability stabilized within 6 months. After two years of Ortho-K, NRA significantly increased (p = 0.044), while it showed no significant difference after one-year of lens wear (p = 0.49). The distance break point in the convergence range showed no significant difference (p = 0.20), but significantly decreased after one-year (p = 0.005). There were no significant correlations between the change in axial length with changes in accommodative or binocular function (p > 0.05).
CONCLUSIONS: Accommodative and binocular function changed significantly after switching from spectacles to Ortho-K and most of the parameters stabilized within the first 6 months. There was no association between the change in accommodative or binocular function and myopia progression.
METHODS: This prospective, self-controlled study followed thirty-six participants (aged 8-14 years) for two years after they switched from spectacles to Ortho-K. Accommodative and binocular function were assessed prior to and 1, 3, 6, 12, 18 and 24 months after commencing Ortho-K. Measurements included accommodative amplitude, accommodative response, accommodative facility, accommodative convergence/accommodation (AC/A), ocular alignment, positive relative accommodation (PRA), negative relative accommodation (NRA), horizontal vergence range, reading ability and stereoacuity. Myopia progression was quantified by the change in axial length.
RESULTS: Ocular alignment, monocular and binocular accommodative facility, and PRA stabilized after 1 month. The distance blur point in the convergence range, the distance break and recovery point in the divergence range, accommodative amplitude, calculated AC/A, stereoacuity and reading ability stabilized within 6 months. After two years of Ortho-K, NRA significantly increased (p = 0.044), while it showed no significant difference after one-year of lens wear (p = 0.49). The distance break point in the convergence range showed no significant difference (p = 0.20), but significantly decreased after one-year (p = 0.005). There were no significant correlations between the change in axial length with changes in accommodative or binocular function (p > 0.05).
CONCLUSIONS: Accommodative and binocular function changed significantly after switching from spectacles to Ortho-K and most of the parameters stabilized within the first 6 months. There was no association between the change in accommodative or binocular function and myopia progression.
摘要：
目的：确定近视眼儿童调节功能和双眼功能变化与近视进展的关系，并确定从眼镜转换为角膜塑形镜（Ortho-K）后视觉功能的变化何时稳定。
方法：这种前瞻性，自我对照研究追踪了36名参与者（年龄在8-14岁之间），他们从眼镜换成了Ortho-K。在开始正交试验之前和之后1、3、6、12、18和24个月评估调节和双眼功能。测量包括调节振幅，宽松的反应，住宿设施，调节会聚/调节(AC/A)，眼对准,正相对适应(PRA)，负相对调节（NRA），水平聚散度范围,阅读能力和立体敏锐度。通过眼轴长度的变化来量化近视进展。
结果：眼睛对齐，单眼和双眼调节设施，PRA在1个月后稳定下来。收敛范围内的距离模糊点，发散范围内的距离突破和恢复点，调节振幅，计算的AC/A，立体敏锐度和阅读能力在6个月内稳定。在Ortho-K工作了两年之后,NRA显著增加（p=0.044），镜片佩戴一年后无显著性差异(p=0.49)。收敛范围内的距离断点没有显着差异（p=0.20），但一年后显著下降(p=0.005)。眼轴长度的变化与调节功能或双眼功能的变化之间没有显着相关性（p>0.05）。
结论：从眼镜切换到Ortho-K后，调节和双眼功能发生了显着变化，并且大多数参数在前6个月内稳定。调节或双眼功能的变化与近视进展之间没有关联。
方法：这种前瞻性，自我对照研究追踪了36名参与者（年龄在8-14岁之间），他们从眼镜换成了Ortho-K。在开始正交试验之前和之后1、3、6、12、18和24个月评估调节和双眼功能。测量包括调节振幅，宽松的反应，住宿设施，调节会聚/调节(AC/A)，眼对准,正相对适应(PRA)，负相对调节（NRA），水平聚散度范围,阅读能力和立体敏锐度。通过眼轴长度的变化来量化近视进展。
结果：眼睛对齐，单眼和双眼调节设施，PRA在1个月后稳定下来。收敛范围内的距离模糊点，发散范围内的距离突破和恢复点，调节振幅，计算的AC/A，立体敏锐度和阅读能力在6个月内稳定。在Ortho-K工作了两年之后,NRA显著增加（p=0.044），镜片佩戴一年后无显著性差异(p=0.49)。收敛范围内的距离断点没有显着差异（p=0.20），但一年后显著下降(p=0.005)。眼轴长度的变化与调节功能或双眼功能的变化之间没有显着相关性（p>0.05）。
结论：从眼镜切换到Ortho-K后，调节和双眼功能发生了显着变化，并且大多数参数在前6个月内稳定。调节或双眼功能的变化与近视进展之间没有关联。
