Abstract：
Exposure to endocrine-disrupting chemicals (EDCs) in freshwater systems has garnered increasing attention. A comprehensive analysis of the migration patterns, bioaccumulation, and consumer health risk of EDCs along the Xiangjiang River due to fish consumption from the river ecosystem was provided. Twenty natural and synthetic target EDCs were detected and analyzed from the water, sediments, and fish samples collected along the Xiangjiang River. There were significant correlations between the EDC concentrations in fish and the sediments. This revealed that EDCs in sediments play a dominant role in the uptake of EDCs by fish. The bioaccumulation factor and biota-sediment accumulation factor were calculated, with the highest values observed for nonylphenol. Pearson\'s correlation analysis showed that bisphenol A is the most reliable biological indicator of EDC contamination in fish. Furthermore, based on the threshold of toxicological concerns and the health risk with dietary intake, crucian carp and catfish from the Xiangjiang River pose a certain risk for children and pregnant women compared to grass carp. The Monte Carlo simulation results indicated a certain risk of cumulative ∑EDC exposure for local residents due to fish consumption.
摘要：
在淡水系统中暴露于内分泌干扰化学物质（EDCs）已引起越来越多的关注。对迁移模式进行了全面分析,生物蓄积性,并提供了由于河流生态系统的鱼类消耗而导致的湘江沿岸EDC的消费者健康风险。从水中检测并分析了20种天然和合成靶标EDC，沉积物,和沿湘江采集的鱼类样本。鱼类中EDC浓度与沉积物之间存在显着相关性。这表明沉积物中的EDC在鱼类吸收EDC中起主导作用。计算了生物累积因子和生物沉积物累积因子，观察到壬基酚的最高值。Pearson相关分析表明,双酚A是鱼类EDC污染最可靠的生物指标。此外，基于毒理学关注的阈值和饮食摄入的健康风险，与草鱼相比，湘江的cru鱼和cat鱼对儿童和孕妇构成一定的风险。蒙特卡罗模拟结果表明，当地居民由于鱼类消费而存在一定的∑EDC累积暴露风险。
