改变 GM1 分解代谢影响 NMDAR 介导的 ER - PM 连接处的 Ca2 + 信号传导, 并增加 GM1 神经节苷脂模型中的突触脊柱形成。
关键词: CP: Cell biology CP: Neuroscience Ca(2+) signaling ER-PM junctions GM1-gangliosidosis NMDAR dendritic spines lysosomal storage disease membrane contact sites synapse
Mesh : Animals Humans Mice Calcium / metabolism Calcium Signaling Cell Membrane / metabolism Dendritic Spines / metabolism Disease Models, Animal Endoplasmic Reticulum / metabolism G(M1) Ganglioside / metabolism Gangliosidosis, GM1 / metabolism pathology Neuronal Plasticity Neurons / metabolism Receptors, N-Methyl-D-Aspartate / metabolism Synapses / metabolism Male Female
来 源:
DOI:10.1016/j.celrep.2024.114117
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