PDF(Pubmed)
Abstract：
A meta-analysis was conducted to comprehensively explore the effects of platelet-rich plasma (PRP) combined with negative pressure wound therapy (NPWT) in treating patients with chronic wounds. Computer searches were conducted, from database infection to November 2023, in EMBASE, Google Scholar, Cochrane Library, PubMed, Wanfang and China National Knowledge Infrastructure databases for randomized controlled trials (RCTs) on the use of PRP combined with NPWT technology for treating chronic wounds. Two researchers independently screened the literature, extracted data and conducted quality assessments according to the inclusion and exclusion criteria. Stata 17.0 software was employed for data analysis. Overall, 18 RCTs involving 1294 patients with chronic wounds were included. The analysis revealed that, compared with NPWT alone, the use of PRP combined with NPWT technology significantly improved the healing rate (odds ratios [OR] = 1.92, 95% confidence intervals [CIs]: 1.43-2.58, p < 0.001) and total effective rate (OR = 1.31, 95% CI: 1.23-1.39, p < 0.001), and also significantly shortened the healing time of the wound (standardized mean difference = -2.01, 95% CI: -2.58 to -1.45, p < 0.001). This study indicates that the treatment of chronic wounds with PRP combined with NPWT technology can significantly enhance clinical repair effectiveness and accelerate wound healing, with a high healing rate, and is worth further promotion and practice.
摘要：
采用Meta分析综合探讨富血小板血浆(PRP)联合负压创面治疗(NPWT)治疗慢性创面的效果。进行了计算机搜索，从数据库感染到2023年11月，在EMBASE中，谷歌学者，科克伦图书馆,PubMed,万方和中国国家知识基础设施数据库关于使用PRP结合NPWT技术治疗慢性伤口的随机对照试验(RCTs)。两名研究人员独立筛选了文献，根据纳入和排除标准提取数据并进行质量评估.采用Stata17.0软件进行数据分析。总的来说,包括18个RCTs，涉及1294例慢性伤口患者。分析显示,与单独的NPWT相比，使用PRP联合NPWT技术显着提高了治愈率（比值比[OR]=1.92，95％置信区间[CI]：1.43-2.58，p<0.001）和总有效率（OR=1.31，95％CI：1.23-1.39，p<0.001），并且也显著缩短了伤口的愈合时间(标准化平均差=-2.01,95%CI:-2.58至-1.45,p<0.001)。本研究表明，PRP联合NPWT技术治疗慢性创面可显著提高临床修复效果，加速创面愈合。有很高的治愈率，值得进一步推广和实践。
