PDF(Pubmed)
Abstract：
The spread of antimicrobial resistance (AMR) is a major global concern, and the islands of the Southwest Indian Ocean (SWIO) are not exempt from this phenomenon. As strategic crossroads between Southern Africa and the Indian subcontinent, these islands are constantly threatened by the importation of multidrug-resistant bacteria from these regions. In this systematic review, our aim was to assess the epidemiological situation of AMR in humans in the SWIO islands, focusing on bacterial species listed as priority by the World Health Organization. Specifically, we examined Enterobacterales, Acinetobacter spp., Pseudomonas spp. resistant to carbapenems, and Enterococcus spp. resistant to vancomycin. Our main objectives were to map the distribution of these resistant bacteria in the SWIO islands and identify the genes involved in their resistance mechanisms. We conducted literature review focusing on Comoros, Madagascar, Maldives, Mauritius, Mayotte, Reunion Island, Seychelles, Sri Lanka, and Zanzibar. Our findings revealed a growing interest in the investigation of these pathogens and provided evidence of their active circulation in many of the territories investigated. However, we also identified disparities in terms of data availability between the targeted bacteria and among the different territories, emphasizing the need to strengthen collaborative efforts to establish an efficient regional surveillance network.
摘要：
抗菌素耐药性(AMR)的散布是全球存眷的主要成绩，西南印度洋（SWIO）的岛屿也不能幸免于这种现象。作为南部非洲和印度次大陆之间的战略十字路口，这些岛屿不断受到从这些地区进口耐多药细菌的威胁。在这次系统审查中，我们的目的是评估SWIO群岛人类AMR的流行病学状况，重点关注世界卫生组织列为优先事项的细菌物种。具体来说,我们检查了肠杆菌,不动杆菌属。,假单胞菌属。耐碳青霉烯类,和肠球菌属。耐万古霉素。我们的主要目标是绘制这些耐药细菌在SWIO岛中的分布图，并确定参与其耐药机制的基因。我们对科摩罗进行了文献综述，马达加斯加，马尔代夫,毛里求斯,马约特岛,留尼汪岛,塞舌尔,斯里兰卡,还有桑给巴尔.我们的发现表明，人们对这些病原体的调查越来越感兴趣，并提供了在许多被调查地区活跃循环的证据。然而,我们还确定了目标细菌之间和不同地区之间的数据可用性方面的差异，强调需要加强合作努力，以建立有效的区域监视网络。
